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Bias and Conditioning in Sequential medical trials
clinical trials frequentism Bayesianism sequential analysis hypothesis test conditioning
2016/5/30
Randomized Controlled Trials (RCTs) are currently the gold standard within evidence-based medicine. Usually, they are conducted as sequential trials allowing for monitoring for early signs of effectiv...
Stopping Rules and Data Monitoring in Clinical Trials
stopping rules neyman-pearson bayes bayesian statistical decision statistical inference
2011/9/8
Philosophers subscribing to particular principles of statistical inference need to be aware of the limitations and practical consequences of the statistical approach they endorse. The framework here p...
It is commonly believed that when a finite value is received in a game that has an infinite expected value, it is in one’s interest to redo the game (note that switching to an unknown but already dete...
Statistical Decisions and the Interim Analyses of Clinical Trials
stopping rules neyman-pearson bayes bayesian statistical decision statistical inference
2011/9/8
This paper analyzes statistical decisions during the interim analyses of clinical trials. After some general remarks about the ethical and scientific demands of clinical trials, I introduce the notion...