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国家自然科学基金委员会北大高宁/李宁宁团队《Cell》发文揭示血红细胞Spectrin-Actin膜骨架系统的组织规则及结构稳定性的分子基础（图）
高宁 李宁宁 细胞 系统 组织 结构 分子
2024/11/21
经典的细胞骨架是由微管（microtubule）、微丝（F-actin）或者中间丝组成的三维网络结构，在细胞的稳定性维持、胞内物质运输以及细胞运动方面发挥关键作用。除此之外，动物细胞中还存在一种以血影蛋白spectrin为基础的二维网状形式的膜骨架系统。膜骨架平行于细胞膜分布，紧贴在细胞膜内侧，赋予细胞膜更高的机械强度和可塑性(Lux, 2016)（图1）。膜骨架与细胞膜的功能活动密切关联：通过与...
近日，中国科学技术大学教授许超课题组与波兰华沙大学Jakub Drozak实验室合作，解析了SETD3与β-actin多肽的高分辨复合物晶体结构，并结合酶活实验揭示了肌动蛋白（Actin）第73位组氨酸（His73）的N3位甲基化的作用机制，相关成果于2月20日以Structural insights into SETD3-mediated histidine methylation on β-a...
中国科学技术大学许超课题组与合作者在《eLife》发文揭示SETD3蛋白作为β-actin组氨酸甲基化酶的结构与功能（图）
中国科学技术大学 许超 课题组 eLife SETD3蛋白 β-actin组 氨酸甲基化酶 结构与功能
2019/3/5
近日，中国科学技术大学许超教授课题组与波兰华沙大学Jakub Drozak实验室合作，解析了SETD3与β-actin多肽的高分辨复合物晶体结构，并结合酶活实验揭示了肌动蛋白（Actin）第73位组氨酸（His73）的N3位甲基化的作用机制，相关成果以“Structural insights into SETD3-mediated histidine methylation on β-actin”...
中国科学技术大学课题组与合作者在《eLife》发文揭示SETD3蛋白作为β-actin组氨酸甲基化酶的结构与功能（图）
中国科学技术大学 SETD3蛋白 β-actin组氨酸 甲基化 酶
2019/2/27
近日，中国科学技术大学许超教授课题组与波兰华沙大学Jakub Drozak实验室合作，解析了SETD3与β-actin多肽的高分辨复合物晶体结构，并结合酶活实验揭示了肌动蛋白（Actin）第73位组氨酸（His73）的N3位甲基化的作用机制，相关成果以“Structural insights into SETD3-mediated histidine methylation on β-actin”...
In response to glucose, pancreatic islet beta cells secrete insulin in a biphasic manner, and both phases are diminished in type 2 diabetes. In beta cells, cortical F-actin beneath the plasma membrane...
ADF/Cofilin Activation Regulates Actin Polymerization and Tension Development in Canine Tracheal Smooth Muscle
dissertations research thesis
2015/5/22
The contractile activation of airway smooth muscle tissues stimulates actin polymerization and the inhibition of actin polymerization inhibits tension development. Actin depolymerizing factor (ADF) an...
ANALYSIS OF AN ACTIN BINDING GUANINE EXCHANGE FACTOR, GEF8, AND ACTIN DEPOLYMERIZING FACTOR IN ARABIDOPSIS THALIANA.
ACTIN BINDING GUANINE EXCHANGE FACTOR GEF 8 ACTIN DEPOLYMERIZING FACTOR ARABIDOPSIS THALIANA
2014/12/12
ANALYSIS OF AN ACTIN BINDING GUANINE EXCHANGE FACTOR, GEF8, AND ACTIN DEPOLYMERIZING FACTOR IN ARABIDOPSIS THALIANA. April, 2010 Aleksey Chudnovskiy, B.S., UNIVERSITY OF MASSACHUSETTS AMHERST M.S., UN...
Modulation of epidermal growth factor receptor function by mutations within the actin -binding domain
Genes actin internalization growth factors tyrosine phenylalanine glutamic acid phenylalanine residues
2014/12/11
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Regulation of the actin cytoskeleton in the pollen tube
Pollen tube ovule sperm plant sexual reproduction actin cytoskeleton protein
2014/12/11
Pollen tube growth, the process that transports the sperm cell to the ovule, is fundamental for plant sexual reproduction. The actin cytoskeleton is essential to the process of pollen tube elongation....
Analysis of the interaction between the epidermal growth factor receptor and actin
Epidermal growth factor protein amino acids growth factors actin cell free system cytosol cells actin immune
2014/12/11
It has been shown that the epidermal growth factor receptor (EGFR) can directly interact with F-actin via an actin-binding domain (ABD) located at amino acid residues 984–996. In this study, we invest...
Cyclooxygenase and cyclic AMP -dependent protein kinase regulate actin organization and cell motility
Cells extracellular matrix cell signal cytoskeleton the cancer cells
2014/12/11
Cell adhesion to an extracellular matrix plays a critical role in many aspects of normal cell function. Cells display various modes of interaction with the extracellular matrix; they may attach and sp...
Organization and dynamics of actin and myosin during cytokinesis in mammalian epithelial cells
Cytokinesis separation of cell division biological process actin polymer structure myosin
2014/12/11
Cytokinesis, the process of physically separating cells for division, requires the precise orchestration of numerous physical, mechanical, chemical and biological processes. For these processes to fun...
Organization and maintenance of the motor nerve terminal: Roles for presynaptic actin and perisynaptic Schwann cells
Frog neuromuscular actin nerve terminals protein cell skeleton
2014/12/11
At the adult frog neuromuscular junctions (Rana pipien and Rana catesbiana), F-actin microfilaments are enriched in the nonrelease domains of nerve terminals, outside the vesicle-rich release sites. T...
猪瘟病毒C蛋白与宿主β-actin相互作用的鉴定
猪瘟病毒 C蛋白 β-actin 病毒-宿主相互作用
2014/12/29
为了研究猪瘟病毒(CSFV)和宿主间的相互作用，采用Co-IP方法，利用CSFV C蛋白从PK-15细胞中钓取与其相互作用的宿主蛋白质，经SDS-PAGE电泳，银染，选取差异条带，进行质谱分析，选取β-actin蛋白作为研究的对象。经内源性Co-IP试验和GST pulldown试验进一步证实CSFV C蛋白和β-actin可以特异性结合，激光共聚焦试验表明两者共定位于细胞质。本研究表明CSFV ...
A constitutive law for cross-linked actin networks by homogenization techniques
A-microstructure B-biological material B-constitutive behavior
2010/11/22
Inspired by experiments on the actin driven propulsion of micrometer sized beads we develop and study a minimal mechanical model of a two-dimensional network of stiff elastic filaments grown from the ...