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Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：On strongly quasiconvex functions: existence results and proximal point algorithms
强准孔函数 存在结果 近端点算法
2023/5/4
The class of strongly quasiconvex functions was introduced in the famous paper of B.T. Polyak in 1966. It is the natural extension of the class of strongly convex functions, its applications emcompass...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Primal Dual Alternating Proximal Gradient Algorithms for Nonsmooth Nonconvex Minimax Problems with Coupled Linear Constraints
耦合 线性约束 非光滑 非凸极小问题 基本对偶交替 近端梯度算法
2023/4/14
Nonconvex minimax problems have attracted wide attention in machine learning, signal processing and many other fields in recent years. In this paper, we propose a primal dual alternating proximal grad...
Proximal Ligand Motions in H93G Myoglobin
resonance Raman heme myoglobin hemoglobin ligand switch
2016/5/24
Resonance Raman spectroscopy has been used to observe changes in the iron-ligand stretching frequency in photoproduct spectra of the proximal cavity mutant of myoglobin H93G. The measurements compare ...
The Role of the Distal and Proximal Protein Environments in Controlling the Ferric Spin State and in Stabilizing Thiolate Ligation in Heme Systems:Thiolate Adducts of the Myoglobin H93G Cavity Mutant
salicylic alcohols hydrogen bonds quantum chemistry
2016/5/23
Recently, heme protein cavity mutants have been engineered in which the proximal coordinating amino acid has been replaced by a smaller, noncoordinating residue leaving a cavity that can be filled by ...
Hydrogen Bonding Modulates Binding of Exogenous Ligands in a Myoglobin Proximal Cavity Mutant
Alanine Amino Acid Substitution Animals Binding Sites Glycine Histidine Hydrogen Bonding Imidazoles Ligands Macromolecular Substances Metmyoglobin Models, Chemical Mutagenesis, Insertional Myoglobin Nitric Oxide Nuclear Magnetic Resonance,Biomolecular Protons Serine Threonine Whales
2016/5/23
In the sperm whale myoglobin mutant H93G, the proximal histidine is replaced by glycine, leaving a cavity in which exogenous imidazole can bind and ligate the heme iron (Barrick, D. (1994) Biochemistr...
Dynamics of Myoglobin-CO with the Proximal Histidine Removed:Vibrational Echo Experiments
Myoglobin-CO Proximal Histidine Removed Vibrational Echo Experiments
2016/5/23
Picosecond infrared vibrational echo measurements from 60 to 300 K on CO bound to the active site of a mutant myoglobin, H93G(N-MeIm), are presented and compared to measurements on native myoglobin an...
Modulation of Protein Function by Exogenous Ligands in Protein Cavities:CO Binding to a Myoglobin Cavity Mutant Containing Unnatural Proximal Ligands
Animals Binding Sites Carbon Monoxide Cloning, Molecular Escherichia coli Heme Kinetics Ligands Magnetic Resonance Spectroscopy Mutagenesis, Site-Directed Myoglobin Myoglobin Point Mutation Protein Conformation ecombinant Proteins Recombinant Proteins Spectroscopy,Fourier Transform Infrared Valine Whales
2016/5/23
A variety of heterocyclic ligands can be exchanged into the proximal cavity of sperm whale myoglobin mutant H93G, providing a simple method for introduction of the equivalent of unnatural amino acid s...
1H NMR Characterization of Myoglobins Where Exogenous Ligands Replace the Proximal Histidine
Sperm whale myoglobin Site-directed mutagenesis Resonance assignment Heme Orientation Imidazole Cyanometmyoglobin Binding Mutants H-1-nmr
2016/5/23
The role of the proximal ligand in determining the structure and ligand binding properties of sperm whale myoglobin has been investigated using the mutant H93G(L), where the proximal histidine has bee...
Spectroscopic Study of Ser92 Mutants of Human Myoglobin:Hydrogen Bonding Effect of Ser92 to Proximal His93 on Structure and Property of Myoglobin
Carbon Monoxide Cyanides Escherichia coli Ferric Compounds Ferrous Compounds Histidine Humans Hydrogen Bonding Magnetic Resonance Spectroscopy Mutagenesis Myoglobin Myoglobin Oxygen Polymerase Chain Reaction Recombinant Fusion Proteins Serine Serine Spectrophotometr Spectrum Analysis, Raman Structure-Activity Relationship
2016/5/23
Neutron diffraction studies have demonstrated that the hydroxyl group oxygen of Ser92(F7) is hydrogen bonded to the proximal His93(48) N epsilon H proton in myoglobin (Mb) [Cheng, X., & Shoenborn, B. ...
Functional Cavities in Proteins:A General Method for Proximal Ligand Substitution in Myoglobin
Functional Cavities Proteins Proximal Ligand Substitution Myoglobin
2016/5/23
Functional Cavities in Proteins:A General Method for Proximal Ligand Substitution in Myoglobin.
Vegetation cover analysis using a low budget hyperspectral proximal sensing system
hyperspectral proximal sensing unable filters vegetation classification
2015/9/7
This report describes the implementation of a hyperspectral proximal sensing low-budget acquisition system and its application to the detection of terrestrian vegetation cover anomalies in sites of hi...
Proximal algorithms
Proximal algorithm optimization algorithm the standard tools smooth moderate scale high dimensional data set
2015/8/7
This monograph is about a class of optimization algorithms called proximal algorithms. Much like Newton's method is a standard tool for solving unconstrained smooth optimization problems of modest siz...
Adolescent Physical Activity and Bone Strength at the Proximal Femurin Adulthood
HIP STRUCTURAL ANALYSIS PHYSICAL ACTIVITY QUESTIONNAIRE LEAN TISSUE MASS BONE GEOMETRY LONGITUDINAL
2017/5/19
Physical activity (PA) enhances bone structural strength at the proximal femur in adolescence, but whether these benefits are maintained into early adulthood remains unknown. The purpose of this study...
Proximal methods for the latent group lasso penalty
Structured sparsity proximal methods regularization
2012/11/23
We consider a regularized least squares problem, with regularization by structured sparsity-inducing norms, which extend the usual $\ell_1$ and the group lasso penalty, by allowing the subsets to over...
Geometric Approximation of Proximal Normals
Nonsmooth analysis distance function $\delta$-projection proximal normal proximal subdifferential
2009/2/5
For $x\in H\setminus S$ and $\delta \ge 0$, the $\delta$-projection of $x$ onto $S$, is the set $\operatorname{proj}_S^\delta(x):=\left\{s\in S \colon \|s-x\|^2 \le d_S(x)^2 + \delta^2 \right\}.$ We p...