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Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. However, for the vast majority of those mutations, researchers are unsure of how they contribute to...
Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful p...
Ateam of researchers led by Harvard and Broad Institute scientists has developed twin prime editing, a new, CRISPR-based gene-editing strategy that enables manipulation of gene-sized chunks of DNA in ...
New programmable gene editing proteins found outside of CRISPR systems（图）
CRISPR系统 可编程基因 编辑蛋白 酶
2023/6/20
Within the last decade, scientists have adapted CRISPR systems from microbes into gene editing technology, a precise and programmable system for modifying DNA. Now, scientists at MIT’s McGovern Instit...
New gene-editing technique shows promise against sickle cell disease（图）
镰状细胞性贫血 基因编辑技术 一次性治疗
2023/6/21
Ateam of researchers led by scientists from Harvard and the Broad Institute used a new gene-editing technique to successfully treat sickle cell disease in mice. This advancement could one day lead to ...
Elizabeth Kellogg, assistant professor of molecular biology and genetics in the College of Arts and Sciences, has been named to the Pew Scholars Program to pursue research into advancing gene editing ...
Light-activated 'CRISPR' enables fast, precise gene editing and detection of DNA repair（图）
Light-activated CRISPR enables fast precise gene editing detection DNA repair
2020/7/3
In a series of experiments co-funded by the National Science Foundation, scientists at Johns Hopkins have used light as a trigger to make quick, precise cuts in the genomic material of ...
Off-Switch for CRISPR-Cas9 Gene Editing System Discovered
Off-Switch CRISPR-Cas9 Gene Editing System
2017/1/9
UC San Francisco researchers have discovered a way to switch off the widely used CRISPR-Cas9 gene-editing system using newly identified anti-CRISPR proteins that are produced by bacterial vi...
New Gene-Editing Technology Cures Genetic Blood Disorder in Mice
New Gene-Editing Technology Cures Genetic Blood Disorder Mice
2016/11/4
A next-generation gene-editing system developed by Carnegie Mellon University and Yale University scientists has cured a genetic blood disorder in living mice using a simple IV treatment. Unlike the p...
Directly Reprogramming a Cell's Identity with Gene Editing
Reprogramming Cell Identity Gene Editing
2016/8/23
Researchers have used CRISPR—a revolutionary new genetic engineering technique—to convert cells isolated from mouse connective tissue directly into neuronal cells.In 2006, Shinya Yamanaka, a professor...
CRISPR-Cas9 gene editing:check three times,cut once
CRISPR-Cas9 gene editing check three times cut once
2015/12/7
Two new studies from UC Berkeley should give scientists who use CRISPR-Cas9 for genome engineering greater confidence that they won’t inadvertently edit the wrong DNA.The gene editing technique, creat...
Gene editing study reveals possible 'Achilles heel' of sickle cell disease
Gene editing study Achilles heel sickle cell disease
2015/9/25
Researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that changes to a small stretch of DNA may circumvent the genetic defect behind sickle cell d...
Researchers Use DNA‘Clews’to Shuttle CRISPR-Cas9 Gene-Editing Tool into Cells
Researchers DNA Clews Shuttle CRISPR-Cas9 Gene-Editing Tool
2015/9/8
CRISPR–Cas9 represents a promising platform for genome editing, yet means for its safe and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers the Cas9 protein...