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New technology tracks role of macrophages in cancer spread（图）
New technology tracks role macrophages cancer spread
2020/11/6
Macrophages, cells that help engulf and destroy harmful organisms in the body, tend to be characterized as the Jekyll and Hydes of the immune system.Macrophages are essential first responders in fight...
The role of STAT1 in Chlamydia-induced type I interferon responses in oviduct epithelium
type I interferon TLR oviduct epithelium
2015/5/21
Progression of Chlamydia into upper reproductive tract epithelium and the induction of subsequent immune responses to infection are major contributors to Chlamydia-induced pathogenesis of the genital ...
Investigating the Role of YSLs in Oryza sativa and Arabidopsis thaliana through RT-PCR and Yeast Functional Complementation
Oryza sativa YSLs
2015/1/6
I would like to thank Elsbeth Walker for giving me the opportunity to complete
my MS degree in her lab. I would also like to thank my committee members, Magdalena
Bezanilla and Ana Caicedo for sitti...
The role of mitochondria and proteasomes in T cell apoptosis
Cell apoptosis cell death cell biology enzyme hydrolysis T cells
2014/12/11
Apoptosis is a type of programmed cell death that is essential for the development and maintenance of tissue homeostasis in multicellular organisms. Because apoptosis is important in many biological s...
Role of lipid signalling pathways in an intra and an extracellular phenomenon
Lipid signal cells nuclear envelope lipid signal cells hela cell the membrane vesicles
2014/12/11
This dissertation is in two parts. The first part investigates the role of lipid signalling pathways in an intracellular phenomenon i.e. the formation of the nuclear envelope. The second part is a stu...
The role of cell cycle progression and cyclin -dependent kinase 2 in thymocyte negative selection
T cells and thymus cells thymus self antigen cells
2014/12/11
Autoreactive, immature T cells (thymocytes) are deleted from the thymus during development by the process of negative selection. This mechanism occurs when the thymocyte, T cell receptor (TCR) recogni...
The role of oxidative stress in apoptosis
Thymus cells thymus thymocyte apoptosis oxidative stress molecular oxygen oxidation of thiol
2014/12/11
Thymocytes undergo negative and positive selection during their development in the thymus. During this selection process, the majority of thymocytes are eliminated by apoptosis. In the first part of t...
The role of Notch in T cell activation and development
To activate T cells incision p53 intracellular domain HES1 genes
2014/12/11
Notch is crucial for multiple stages of T cell development, including the CD4+CD8+ double positive (DP) to CD8 + single positive (SP) transition, but regulation of Notch activation is not well underst...
NIH 3T3 fibroblast adhesion to a fibronectin substrate: The role of the arachidonic acid signaling pathway
Cell adhesion and extracellular matrix intracellular signal four acid cervical cancer cells fibers fibronectin matrix and fiber cells
2014/12/11
Cell adhesion to the extracellular matrix initiates a cascade of intracellular signaling pathways via integrin activation. Activation of the arachidonic acid (AA) signaling pathway has been shown to b...
The role of inositol 1,4,5 -trisphosphate receptor type-1 in regulation of intracellular calcium oscillations in mouse eggs
Calcium mammals fertilization eggs activation embryonic development cell cycle inositol receptor
2014/12/11
Calcium ([Ca2+]i) oscillations, a hallmark of mammalian fertilization, are essential to induce egg activation and embryonic development. As the zygotes transition through the cell cycle, these [Ca 2+]...
The role of GTP regulation in chloroplast import
Chloroplasts organelles plant cells photosynthesis amino acids lipid synthesis cell signal
2014/12/11
Plastids (e.g. chloroplasts) are a diverse group of interrelated organelles that have evolved to perform numerous and diverse metabolic processes within all plant cells, including essential roles in p...
Environmental toxicants and white matter composition: Understanding the role of thyroid disruption
Chemicals thyroid hormone brain development environmental toxicology polychlorinated biphenyls (PCBS) neurological deficit
2014/12/11
It is becoming increasingly clear that chemicals present in the environment can interfere with thyroid hormone (TH) action and signaling. This is of great concern because TH is critical for normal bra...
The role of ovarian hormones in p53-mediated resistance to mammary tumorigenesis
Pregnant breast cancer rodents estrogen and progestogen therapy breast cancer the incidence of a disease
2014/12/11
A full term pregnancy reduces breast cancer by up to 50%. In rodents, pregnancy or treatment with estrogen and progesterone to mimic pregnancy reduces mammary tumor incidence. The molecular mechanisms...
Regulation of Notch signaling by the E3 ubiquitin ligase Cbl-b and its role in CD4+ T cell anergy
Cell life cycle T cell signal T cell activation and E3 ubiquitin ligase
2014/12/11
Notch signaling is an evolutionarily conserved pathway that mediates a variety of cell fate decisions. In the immune system, the Notch pathway plays an important role throughout the life of T cells. C...
The Role Of ERα, ERβ And Phytoestrogens From Soy In P53- Mediated Response To Dna Damage In Mammary Epithelium
Biological sciences Breast cancer Estrogen receptors Mammary tumors p53 Phytoestrogens DNA damage
2014/12/11
Estrogenic compounds can stimulate proliferation of the mammary epithelium, but also potentiate the activity of the p53 tumor suppressor protein. These contradictory activities of estrogenic compounds...