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Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
insulin sensitivity mitochondrial capacity obesity polyphenols resveratrol
2018/12/3
Background: The obese insulin-resistant state is characterized by impairments in lipid metabolism. We previously showed that 3-d supplementation of combined epigallocatechin-3-gallate and resveratrol ...
Mitochondrial potassium transport: the role of the MitoKATP
MitoKATP Mitochondrial potassium transport
2014/3/31
Mitochondria are structurally complex. The inner membrane contains the essential components of the electron transport proteins and all of the exchange carriers.
Activation of Mitochondrial ATP-Dependent Potassium Channels by Nitric Oxide
ischemic preconditioning nitric oxide myocytes mitochondria
2014/3/31
We measured mitochondrial redox potential as an index of mitoKATP
channel opening in rabbit
ventricular myocytes. The NO donor S-nitroso-N-acetyl- DL-penicillamine (SNAP, 0.1 to 1 mmol/L) oxidized t...
Mitochondrial ATP-Sensitive Potassium Channel Activation Protects Cerebellar Granule Neurons From Apoptosis Induced by Oxidative Stress
Mitochondrial ATP-Sensitive Oxidative Stress
2014/3/31
ptosis contributes to ischemic injury in the brain,
4
and
brain mitochondria contain 7 times more mitoK
ATP
channels
than heart mitochondria.
5
Several reports have shown that
mitoKATP
chann...
Sketch map showing the structure of mitochondria (on the left ) and principle of generation of MMP in mitochondria. Electron transport system (ETS) pumps protons across the inner mitochondrial membr...
Investigation of the subunit compositi on and the pharmacology of the mitochondrial ATP-dependent K + channel in the brain
ATP-dependent potassium channel Ischemic preconditioning Mitochondrial nitric oxide synthase mtNOS Sulfonylurea recepto
2014/3/31
Selective activation of mitoK
AT P
channels can protect the brain or cultured neurons against a variety of anoxic or metabolic challenges.
However, little is known about the subunit composition or ...