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Low serum ω-3 and ω-6 polyunsaturated fatty acids and other metabolites are associated with poor linear growth in young children from rural Malawi
arachidonic acid carnitine dehydroepiandrosterone docosahexaenoic acid malnutrition pregnenolone sulfate stunting
2018/11/21
Background: Stunting affects ～25% of children <5 y of age and is associated with impaired cognitive and motor development and increased morbidity and mortality. The pathogenesis of stunting is poorly ...
Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial
EPA DHA macrophage lipolysis inflammation insulin resistance
2018/11/14
Background: Increased omega-3 (n–3) fatty acid consumption is reported to benefit patients with metabolic syndrome, possibly due to improved adipose tissue function.
Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction
obesity liver steatosis insulin resistance intestinal permeability gut barrier
2018/11/12
Background: Obesity and associated metabolic disorders are related to impairments of the intestinal barrier.
Objective: We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with...
Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study
fatty acid cholesteryl ester phospholipid desaturase elongase intervention diet physical activity children
2018/12/14
Background: Evidence on the effects of lifestyle interventions on plasma fatty acid composition in children is limited.
Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study
fatty acid cholesteryl ester phospholipid desaturase elongase intervention diet physical activity children
2018/12/18
Background: Evidence on the effects of lifestyle interventions on plasma fatty acid composition in children is limited.
Targeted delivery of short-chain fatty acids to the human large bowel
Targeted delivery short-chain fatty large bowel
2018/11/30
The cecum and colon are an integral, but somewhat neglected, part of the human digestive system. This digestion is affected not by human enzymes but by the microbiota that degrade undigested dietary c...
Impairment of lysophospholipid metabolism in obesity: altered plasma profile and desensitization to the modulatory properties of n–3 polyunsaturated fatty acids in a randomized controlled trial
lysophospholipid metabolism lysophosphatidylcholine lysophosphatidylethanolamine obesity insulin resistance inflammation fatty
2018/12/13
Background: Plasma lysophospholipids have emerged as signaling molecules with important effects on inflammation, insulin resistance, and fatty liver disease, each of which is linked closely to obesity...
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level
fatty liver gene expression liver injury metabolomics transaminases
2018/11/27
Background: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental cha...
Long-chain polyunsaturated fatty acids and the preterm infant: a case study in developmentally sensitive nutrient needs in the United States
LC-PUFA preterm infants docosahexaenoic acid arachidonic acid essential fatty acids
2018/11/28
The vast majority of infant formulas in the United States contain the long-chain polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (22:6n–3) and arachidonic acid (20:4n–6), which were first per...
Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium
arachidonic acid genome-wide association meta-analysis phospholipid trans fatty acids
2018/12/20
Background: Circulating trans fatty acids (TFAs), which cannot be synthesized by humans, are linked to adverse health outcomes. Although TFAs are obtained from diet, little is known about subsequent i...
Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis
palmitoleic fatty acid VLDL triacylglycerol biomarker lipogenesis stearoyl-CoA desaturase
2018/12/19
Background: Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16:1n–7 to 16:0 [SCD1(16)] in plasma...
Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results, and implications
Infant nutrition n23 fatty acids docosahexaenoic acid long-chain polyunsaturated fatty acids visual development
2016/6/3
Animal and human studies have documented
several effects of different dietary and tissue concentrations of
long-chain polyunsaturated fatty acids (LCPUFAs) on retinal
function and vision. The enhan...
Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation
Docosahexaenoic acid (DHA) n23 long-chain polyunsaturated fatty acids n23 LCPUFA pregnancy lactation, breast-feeding breast-fed infants preterm infants term infants
2016/6/3
Much interest has been expressed about the
long-chain polyunsaturated fatty acid (LCPUFA) requirements
of both preterm and term infants, whereas relatively little
attention has been given to the LC...
Importance of n23 fatty acids in health and disease
n23 Fatty acids docosahexaenoic acid, atherosclerosis coronary heart disease inflammatory diseases behavioral disorders
2016/6/3
In the past 2 decades, views about dietary n23
fatty acids have moved from speculation about their functions to
solid evidence that they are not only essential nutrients but also
may favorably modu...
Polyunsaturated fatty acids in the food chain in the United States
Highly unsaturated fatty acids a-linolenic acid eicosapentaenoic acid docosahexaenoic acid n26 fatty acids n23 fatty acids
2016/6/3
In the United States, intake of n23 fatty acids
is <1.6 g/d (<0.7% of energy), of which 1.4 g is a-linolenic acid
(ALA; 18:3) and 0.1–0.2 g is eicosapentaenoic acid (EPA; 20:5)
and docosahexaenoic ...