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Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
cyclophosphamide chemosensitivity structure activity relationships cell culture
2015/5/25
ALDH isoenzymes are known to impact the sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs. Despite its bone marrow toxicity, cyclophos-phamide is still used to treat var...
Patients with resected colon cancer (stage III [T1 to T4, N1-N2] or high-risk stage II [T3 or T4, N0]) or stage II/III rectal cancers (T3 or T4, N0-2) are at significant risk of local and distant fail...
Local therapy in a systemic world: the evolution and incarnations of adjuvant radiotherapy for breast cancer
Local therapy in a systemic world the evolution and incarnations adjuvant radiotherapy breast cancer
2015/3/23
Alan Coates’ career has seen the evolution of radiotherapy in the adjuvant treatment of breast cancer move from the only modality available, through a period of little utilisation, to its current resu...
The effect of adjuvant chemotherapy on cognitive functioning in early breast cancer: implications for outcomes research and oncology practice
cognitive functioning early breast cancer outcomes research oncology practice
2015/3/19
Outcomes research is an important focus of public and research policy in Australia. Recent reports of cognitive impairment after chemotherapy for breast cancer have highlighted the emerging importance...
Delivery of adjuvant chemotherapy (AC) to veterans with resected colon cancer
Colon cancer Veterans Chemotherapy Health services research
2014/12/3
Patients with incomplete administration of AC for colon cancer (CC) likely experience inferior survival while oxaliplatin- and capecitabine-containing AC may not improve survival for older patients. T...
Effects of Exercise during Adjuvant Chemotherapy on Breast Cancer Outcomes
PHYSICAL,ACTIVITY DISEASE-FREE SURVIVAL RANDOMIZED,CONTROLLED,TRIAL RECURRENCE SURVIVAL
2017/5/24
Observational studies suggest that physical activity after a breast cancer diagnosis is associated with improved cancer outcomes; however, no randomized data are available. Here, we report an explorat...
Ultrasound-Guided Peri-Lymphatic and Peri-Neural Corticosteroid Injection as an Adjuvant to Pain and Lymphedema Management in Terminal Cancer: Two Case Reports
Corticosteroids Adjuvant Cancer Pain Lymphedema Peripheral Nerve Block
2013/1/30
We are reporting two patients presented with intractable cancer pain that was treated with a novel application of an ultrasound-guided peripheral nerve block using corticosteroid. This technique offer...
IMT504: A New and Potent Adjuvant for Rabies Vaccines Permitting Significant Dose Sparing
IMT504 Adjuvant Rabies Vaccine Human Animal
2013/2/20
Background: Rabies virus infection causes encephalitis, which is almost always fatal. Vaccination can be extremely effective at preventing disease but is prohibitively costly. Vaccine formulations all...
The effects of adjuvant therapies for sepsis on hepatic and renal function: a retrospective analysis of 108 ICU patients
Sepsis hepatic functions renal functions activated protein C intravenous immunoglobulin
2010/12/21
As liver and kidney failure have a direct effect on mortality, morbidity, and intensive care unit (ICU) length of stay in sepsis patients, maintaining their functions or minimizing the degree of failu...
Assessment of Ketamine Effect as Adjuvant to Morphine in Post-Operative Pain Reduction in Donor Kidney Transplanted
Ketamine Morphine Pain Analgesia Post-operation
2015/9/22
Background: Morphine is a strong analgesic agent being used in acute pain but adverse effects may lead to its discontinuation before sufficient pain relief is obtained. Ketamine is an anti-nociceptive...
The Malarial Metabolite Hemozoin and Its Potential Use as a Vaccine Adjuvant
adjuvant allergy hemozoin innate and adaptive immunity malaria NLRP3 TLR9
2010/11/12
Hemozoin, a bio-crystalline substance, is a hemin detoxification by-product of malaria parasites. The role of hemozoin crystals in host immune system modulation by malaria parasites, and how they inte...
Adjuvant effects of Sophy β-glucan on H5N1 and H5N2 vaccination using a mouse model
β-glucan H5N1 and H5N2 vaccine Immunostimulation
2010/12/10
Sophy β-glucan, a type of β-1,3-1,6 glucan produced by a black yeast Aureobasidium pollulans strain AF0-202, is currently approved for use as a health food supplement. The new genotypic avian influenz...
Analysis of the Effect of Radiotherapy on Malignant Pleural Mesothelioma when Given on Adjuvant or Palliative Basis
Maligant Pleural Mesothelioma Radiotherapy
2013/12/9
Background and objective This retrospective study was designed to evaluate the response and survival of malignant pleural mesothelioma to radiotherapy when delivered with surgery and chemotherapy and ...
Analysis of the Effect of Radiotherapy on Malignant Pleural Mesothelioma when Given on Adjuvant or Palliative Basis
Maligant Pleural Mesothelioma Radiotherapy
2013/12/9
Background and objective This retrospective study was designed to evaluate the response and survival of malignant pleural mesothelioma to radiotherapy when delivered with surgery and chemotherapy and ...
Contralateral effect of adjuvant induced monoarthritis
LDI Adjuvant Contralateral adjuvant monoarthritis
2009/12/30
Experiments wee performed to evaluate the contralateral effect of adjuvant induced mono arthritis. In these experiments Laser Doppler imaging (LDI) was used to investigate changes in blood flow. Adjuv...