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探讨外层致密纤维(outer dense fobres，ODF)在Akap4基因缺陷引起小鼠精子尾部多种形态异常中的作用。方法：通过基因编辑技术构建Akap4基因缺陷小鼠模型。实验分为2组：成年Akap4基因缺陷雄鼠为实验组(n=7)，成年野生型雄鼠为对照组(n=7)，比较2组小鼠的体重和睾丸重量；采用计算机辅助精液分析(computer aided sperm analysis，CASA)检测精...
Molecular genetic analysis of two human sperm fibrous sheath proteins, AKAP4 and AKAP3, in men with dysplasia of the fibrous sheath
human sperm fibrous sheath proteins AKAP4 AKAP3 dysplasia
2008/12/26
Dysplasia of the fibrous sheath (DFS) is characterized by male infertility, asthenozoospermia, and morphologically abnormal flagella that possess a severely malformed fibrous sheath. In many cases, DF...