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Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2
SARS-CoV-2 human ACE2 transgenic mouse COVID-19 pneumonia
2020/6/11
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angi...
Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system
angiotensin-converting enzyme inhibitor β-blocker hypertension nutrition potassium
2018/12/18
Background: Reduced potassium excretion caused by angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) may increase the risk of hyperkalemia (serum potassium conce...
Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (rs4646994) and VEGF Polymorphism (+405G/C; rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes
Vascular Endothelial Growth Factor Albuminuria Diabetes Mellitus Genetic Polymorphism
2015/10/20
Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and vascular endothelial growth factor (VEGF) polymorphisms have been shown to associate with diabetic nephropathy (DN).
Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism
Renin-angiotensin system Angiotensin converting enzyme 2 Angiotensin (1-7) Pulmonary embolism Right ventricle
2014/11/28
Right ventricular (RV) dysfunction contributes to poor clinical prognosis after pulmonary embolism (PE). The present studies evaluate the effects of angiotensin (1-7) (ANG (1-7)) upon RV function duri...
Inhibition of the Renin Angiotensin System during Autologous Stem Cell Transplant Does Not Impact Time to Engraftment
Multiple Myeloma ACE Inhibitor Angiotensin Receptor Blocker Melphalan Neutropenia
2013/1/30
Background: The renin angiotensin system RAS modulates hematopoiesis via local effects in the bone marrow. Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) may ...
STUDY OF CORRELATION BETWEEN SYSTOLIC BLOOD PRESSURE AND ANGIOTENSIN CONVERTING ENZYME (ACE) ACTIVITY IN STZ INDUCED DIABETIC RATS
STZ induced diabetic rats Diabetes mellitus morbidity mortality
2010/1/6
Background: Diabetes mellitus is a worldwide health problem affecting 1-2% of the population. It is responsible for numerous morbidity and mortality consequences due to vascular events such as hyperte...
Angiotensin Converting Enzyme Activity in the Serum, Lung, Liver and Kidney in Streptozotocin -Induced Diabetic Rats and Diabetic Nephropathy
Angiotensin Converting Enzyme Streptozotocin-Diabetes Nephropathy
2009/7/2
To clarify the relationship between the alterations of the levels of angiotensin converting enzyme (ACE) and diabetic nephropathy, ACE activity in the lung, liver, kid-ney and serum were investigated ...
The Role of Renin-Angiotensin System in Regulating Fibrinolytic Balance:Potential Mechanism in Prevention of Myocardial Infarction
Renin angiotensin myocardial infarction fibrinolysis
2009/6/30
Over the last two decades, there has been an impressive growth of experimental and clinical evidence defining a role for the renin-angiotensin system (RAS) in the development of ischemic cardiovascul...
Effects of Angiotensin Converting Enzyme Inhibitors in Healthy Rats and in Rats With Carbon Tetrachloride-Induced Toxic Hepatitis
Captopril enalapril carbon tetrachloride hepatotoxicity
2009/6/30
Sulphydryl-containing captopril (CPR) appears to act as a scavanger of oxygen derived free radicals. This is not present in other angiotensin-converting enzymes such as enalapril (EPR). The hepatotoxi...
目的： 在钙化大鼠主动脉血管平滑肌细胞上观察血管紧张素-(1-7)［Angiotensin-(1-7)］对钙化的影响及其信号通道。方法: 用β-磷酸甘油制备钙化的大鼠血管平滑肌细胞，再以血管紧张素-(1-7)、血管紧张素Ⅱ、血管紧张素Ⅱ +血管紧张素-(1-7)、选择性蛋白激酶A（PKA）或蛋白激酶C（PKC）抑制剂等干预，通过Von Kossa染色及检测钙含量、碱性磷酸酶活性、骨钙素浓度和Cbf...
An Angiotensin II (Ang II) Type 1 Receptor Blocker, Telmisartan, Improves Insulin Resistance in KK-Ay Diabetic Mice
telmisartan insulin resistance hypertension diabetes PPAR-γ
2009/4/20
Metabolic syndrome is strongly associated with insulin resistance and consists of a constellation of factors such as hypertension and hyperlipidemia that raise the risk for cardiovascular diseases and...
Release of angiotensin-converting enzyme（ACE）from human spermatozoa during capacitation and acrosome reaction
ACE content ejaculate kininase II
2009/2/13
The present study examines the release of angiotensin-converting enzyme (ACE) from human spermatozoa during capacitation conditions and in correlation to acrosome reaction and cell death. The ACE ...
Restoration of Erectile Capacity in Normotensive Aged Rats by Modulation of Angiotensin Receptor Type 1
Erectile dysfunction Sprague-Dawley rat losartan
2008/12/23
We investigated the effects of systemic modulation of angiotensin 2 on the erectile dysfunction of aged rats. Young and aged (18 months old) male Sprague-Dawley rats were either treated with daily a...
Medicinal Chemistry and Therapeutic Relevance of Angiotensin-Converting Enzyme Inhibitors
medicinal chemistry angiotensin converting enzyme inhibitors (ACEIs) therapeutics critical thinking
2018/5/2
Chemical Basis of Drug Action (PHA337 and PHA447) is a required 2-semester course sequence taught to second-professional year pharmacy students at Creighton University in both the campus and distance-...
Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy
Angiotensin converting enzyme Genetic polymorphism Insertion/deletion Diabetic nephropathy Iran
2010/2/1
Angiotensin I-converting Enzyme (ACE) gene polymorphism; genotype DD or D allele may be involved with an increased susceptibility to type 2 diabetes and diabetic nephropathy (DN). We examined the freq...