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Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors（图）
癌细胞 选择性加载 T细胞 浸润肿瘤
2023/7/7
Checkpoint inhibitor drugs have been a gamechanger for many cancer patients. Yet around 70% don’t respond to these medications, which work by removing the “brakes” on the immune system’s response to a...
Differences in T cells’ functional states determine resistance to cancer therapy（图）
T细胞 癌症治疗 耐药性
2023/6/6
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by ...
Researchers at MIT and Dana-Farber Cancer Institute have developed a new way to determine whether individual patients will respond to a specific cancer drug or not. This kind of test could help doctor...
As tumors grow within an organ, they also release cells that enter the bloodstream. These cells can travel to other organs, seeding new tumors called metastases.
Extracellular vesicles (EVs), nanometer-sized messengers that travel between cells to deliver cues and cargo, are promising tools for the next generation of therapies for everything from autoimmune an...
重庆医科大学附属第一医院欧云生教授团队在《Science》发表RNA疫苗增强claudin-CAR-T cells对实体瘤疗效的相关学术评论文章（图）
重庆医科大学附属第一医院 欧云生教授 Science RNA疫苗增强 claudin-CAR-T cells 实体瘤疗效 相关学术 评论文章
2020/9/22
重庆医科大学附属第一医院欧云生教授带领的科研团队撰写对论文“An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors”【Science 2020 367(6476):446-453】进行评论的论文在线刊登于Science期刊网站的官方平台。第一作者为重庆医科大学2014级临床医学...
Novel, label-free imaging technique brings out the inner light in T cells（图）
Novel label-free imaging technique brings out inner light T cells
2020/7/31
T cells are the immune soldiers at the frontline of the battle with infiltrating pathogens that seek to cause disease. A new studypublished in Nature Biomedical Engineering describes a ...
2019年11月13日，浙江大学医学院附属口腔医院王慧明教授团队在STEM CELLs（干细胞领域权威期刊之一）上在线发表题为“KLF2+ stemness maintains human mesenchymal stem cells in bone regeneration”的研究论文，首次提出采用KLF2作为人骨髓间充质干细胞(hMSCs)体外标志物，并研究KLF2+hMSCs在血管再生和骨组...
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells
SARS-CoV-2-encoded nucleocapsid protein acts viral suppressor of RNA interference cells
2020/6/12
We thank Prof. Peng Zhou (Wuhan, China) for kindly providing materials and thank Yan Wu and Weijuan Shang for experimental assistance. This work was supported by the Strategic Priority Research Progra...
An Anti-Aging Protein Could Be Targeted to Rejuvenate Immune Cells
Anti-Aging Protein Rejuvenate Immune Cells
2017/12/19
Anti-aging proteins have long been shown to protect against age-related diseases, such as cancer, neurodegeneration, and cardiovascular disease. A study by researchers at the Gladstone Institutes now ...
Study finds a new way to shut down cancer cells’ ability to consume glucose（图）
shut down cancer cells ability to consume glucose
2017/11/23
Cancer cells consume exorbitant amounts of glucose, a key source of energy, and shutting down this glucose consumption has long been considered a logical therapeutic strategy. However, good pharmacolo...
Smart Artificial Beta Cells Could Lead to New Diabetes Treatment（图）
Smart Artificial Beta Cells New Diabetes Treatment
2017/11/23
Treating type 1 diabetes and some cases of type 2 diabetes has long required painful and frequent insulin injections or a mechanical insulin pump for insulin infusion. But researchers from the Univers...
Smart molecules trigger white blood cells to become better cancer-eating machines
Smart molecules trigger blood cells cancer-eating machines
2017/10/25
A team of researchers has engineered smart protein molecules that can reprogram white blood cells to ignore a self-defense signaling mechanism that cancer cells use to survive and spread in the body. ...
UA Cancer Center Team Identifies a Switch that May Help Target Dormant Cancer Cells（图）
UA Cancer Center Team Dormant Cancer Cells
2017/10/24
A study by scientists at the University of Arizona and the University of Pittsburgh may hold the key to targeting dormant — or inactive —cancer cells, which are resistant to chemotherapy and other tre...
Spaser Can Detect,Kill Circulating Tumor Cells to Prevent Cancer Metastases,Study Finds
Spaser Can Detect Kill Circulating Tumor Cells Prevent Cancer Metastases
2017/9/5
A nanolaser known as the spaser can serve as a super-bright, water-soluble, biocompatible probe capable of finding metastasized cancer cells in the blood stream and then killing these cells, according...