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Role of protein kinase A in the inhibition of human mast cell histamine release by β-adrenergic receptor agonists
β-adrenergic receptor agonist histamine release human cultured mast cells protein kinase A protein kinase C
2010/11/24
Stimulation of mast cells induced the elevation of intracellular cytosolic free Ca2+ concentrations ([Ca2+]i) and the translocation of protein kinase C (PKC) from the cytosol to the cell membrane, fol...
Dose-response relationship for inhaled corticosteroids and the add-on effect of long-acting β2-adrenergic receptor agonists in adult chronic asthmatics
add-on effect bronchial asthma dose-response relationship inhaled corticosteroids long-acting β2adrenergic receptor agonist
2010/11/22
Therapy with inhaled corticosteroids (ICS) has been regarded as first-line treatment for persistent asthma because of its highly potent anti-inflammatory effects. However, the limitations of such ther...
Clinical Use of β2-adrenergic Receptor Agonists Based on Their Intrinsic Efficacy
airway smooth muscle bronchial asthma desensitization Gs long-acting β2-agonists Rho β2-adrenergic receptors
2010/11/19
Clinical choice of β2-adrenergic receptor agonists (β2-agonists) is based on the parameter of receptor selectivity, potency, and duration of action. The guidelines for asthma management describe nothi...
β3-Adrenergic Receptor Agonists and Other Potential Anti-obesity Agents
obesity anti-obesity drugs adrenergic receptor agonists
2018/3/26
Obesity is reaching epidemic proportions in America and rising at an alarming rate throughout the world. The morbidity of cardiovascular disease, diabetes, osteoarthritis, and some cancers increases i...