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目的: 探讨颗粒溶素(granulysin, GNLY)在原发性胆汁性肝硬化和患者(PBC)中的表达及其意义. 方法: 采用TaqMan探针技术, 以18S rRNA为内参照, 测定60例PBC患者外周血中GNLY mRNA的含量, 同时应用酶联免疫吸附法(ELISA), 检测PBC患者血清中GNLY蛋白的水平,并以健康体检组(n = 100)和乙型肝炎肝硬化组(n = 60)为对照. 结果: P...
Granulysin is a recently characterized cytotoxic granule expressed in cytotoxic T cells and NK cells. Although its cytotoxic effect against a number of tumor cell lines has been demonstrated in vitro,...