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Effect of Suplatast Tosilate on Antileukotriene Non-Responders with Mild-to-Moderate Persistent Asthma
antileukotriene non-responders bronchial asthma children suplatast tosilate Th2 cytokines
2010/11/16
ST is a good choice for patients who have failed to respond to LTRAs. ST should therefore be added to the list of treatment options for such patients.
Suplatast/Tacrolimus Combination Therapy for Refractory Facial Erythema in Adult Patients with Atopic Dermatitis—A Meta-Analysis Study—
atopic dermatitis erythema meta-analysis suplatast tacrolimus
2010/11/18
Background: Combination of suplatast tosilate with tacrolimus ointment was reported to reduce the dose of tacrolimus ointment with maintained treatment efficacy for refractory facial erythema in atopi...
Effect of suplatast tosilate on cough variant asthma
asthma capsaicin cough threshold cough variant asthma eosinophilic cationic protein suplatast T helper 2 cell-derived cytokine inhibitor
2010/11/25
A 40-year-old female patient with chronic persistent cough was diagnosed with cough variant asthma (CVA). To investigate the effect of suplatast tosilate (suplatast, 300 mg/day, three times a day), co...
Identifying Predictors of Response to Suplatast Tosilate among Patients with Moderate to Severe Bronchial Asthma Receiving Inhaled Steroid Therapy
antiasthmatic agent basophil bronchial asthma eosinophil response prediction
2010/11/22
Twenty-two patients were assessed as responders according to our criteria. The percentage of blood eosinophil (%EOS, P = 0.015) and basophil (%BASO, P = 0.019) counts were identified as significant va...
The Effect of Suplatast Tosilate on TARC Production in Peripheral Blood Mononuclear Cells and TARC Plasma Levels
allergic rhinitis chemokines suplatast tosilate TARC
2010/11/22
Suplatast tosilate significantly reduced TARC production by PBMCs. TARC mRNA was also suppressed in a concentration dependent manner. However, suplatast tosilate did not inhibit the expression of CCR-...
Suplatast Tosilate Inhibits Human Mast Cell Development from Cord Blood Progenitors
cord blood progenitors human mast cells stem cell factor suplatast tosilate
2010/11/19
Background: Localized mast cell accumulation has been reported in a number of human diseases. Suplatast tosilate has been reported to inhibit IL-3-dependent murine mast cell development, and therefore...
Usefulness of Suplatast Tosilate in Patients with Mild Bronchial Asthma —Comparison with Beclomethasone Dipropionate
airway hypersensitivity anti-allergic agents antiasthmatic drugs bronchial asthma inflammatory mediators
2010/11/19
The suplatast tosilate group required more time than the BDP group to show improvement in peak expiratory flow, but at week 6 the change from baseline was nearly the same in both groups. A significant...