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Adhesion of Beta1 Integrin to Fibronectin Regulates CAM-DR Phenotype via p21WAF1/cip1 in HL60 Acute Myeloid Leukemia (AML) Cells
Apoptosis CAM-DR fibronectin cell cycle
2009/6/16
Aims: Drug resistance is a major obstacle for a successful cancer therapy. Cell adhesion mediated drug resistance (CAM-DR) is a novel type of drug resistance and generated via interaction of cancer ce...
探讨了integrin β1在不同细胞周期人肝癌细胞（SMMC-7721）上的表达和在肝癌细胞与人脐静脉内皮细胞粘附过程中的作用。未同步处理的肝癌细胞（对照组）各细胞周期时相百分比为G0/G1期53.51%、G2/M期11.01%、S期35.48%，采用胸腺嘧啶脱氧核苷、秋水仙碱顺序阻断和胸腺嘧啶脱氧核苷双阻断后释放培养的方法获得G1期和S期的肝癌细胞，其同步率分别为74.09%和98.29%...
β2 Integrin-dependent tyrosine phosphorylation of proline-rich tyrosine kinase 2 in platelet-activating factor-activated eosinophils
degranulation eosinophil β2 integrin PYK-2 tyrosine phosphorylation
2010/11/26
Platelet-activating factor (PAF) can activate various cellular functions, including degranulation in eosinophils. In the present study, we examined tyrosine phosphorylation of intracellular proteins i...
Elevation of the Soluble form GPI-80, a β2 Integrin-associated Glycosylphosphatidylinositol Anchored Protein, in the Serum of Patients with Wegener's Granulomatosis
anti-neutrophil cytoplasmic antibodies enzyme-Linked immunosorbent assay neutrophils tumor necrosis factor receptors Wegener's granulomatosis
2010/11/19
Background: The purpose of present study is to determine the value of serum levels of the soluble form of β2 integrin-associated glycosylphosphatidylinositol (GPI)-anchored glycoprotein (GPI-80) for m...