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β2 Integrin-dependent tyrosine phosphorylation of proline-rich tyrosine kinase 2 in platelet-activating factor-activated eosinophils
degranulation eosinophil β2 integrin PYK-2 tyrosine phosphorylation
2010/11/26
Platelet-activating factor (PAF) can activate various cellular functions, including degranulation in eosinophils. In the present study, we examined tyrosine phosphorylation of intracellular proteins i...
Platelet-activating Factor or Complement 5a Causes Distinct Activation Profiles in Human Eosinophil and Neutrophil Functions
adhesion complement 5a eosinophils neutrophils platelet-activating factor superoxide anion β2 integrin
2010/11/19
Eosinophils and neutrophils showed different activation profiles with stimulation of PAF or C5a on HSA-coated surfaces. In eosinophils the intensity of cellular adhesion and O2- release paralleled the...