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Synthesis and Mechanistic Studies of a Novel Homoisoflavanone Inhibitor of Endothelial Cell Growth
Endothelial Cell Growth Synthesis and Mechanistic
2014/11/25
Preventing pathological ocular angiogenesis is key to treating retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. At present there is no small molecule drug on the ...
Successful Management of Total Knee Replacement in a High Responder Hemophilia Patient With a History of Inhibitor
Orthopedics Hemophilia A Hemophilia B Inhibitor
2015/9/29
The development of inhibitors against administered clotting factors may render replacement therapy ineffective for some hemophilia patients. Such patients are therefore at the highest risk of developi...
Comparison of Oral and Intravenous Proton Pump Inhibitor on Patients with High Risk Bleeding Peptic Ulcers: A Prospective, Randomized, Controlled Clinical Trial
Proton pump inhibitor Bleeding Peptic ulce
2015/9/23
Background: Proton pump inhibitors (PPIs) decrease the rate of rebleeding following endoscopic hemostatic therapy in patients with bleeding peptic ulcers. This study compares the efficacy of oral omep...
The association of TAFI (Thrombin-activatable fibrinolysis inhibitor) with insulin resistance and components of metabolic syndrome in patients with metabolic syndrome
Metabolic syndrome TAFI insulin resistance
2010/11/22
To investigate the association of TAFI with components of metabolic syndrome and insulin resistance in patients with metabolic syndrome. Materials and methods: Patients between 20 and 70 years of age,...
Clostridium Difficile Associated Diarrhoea and the Rela-tionship to Antibiotic Prescription Practices and Proton Pump Inhibitor Use in Elderly Wards
Clostridium Difficile Diarrhoea Antibiotic Proton pump inhibitor Elderly
2015/9/22
Background: Clostridium difficile-associated diarrhoea (CDAD) is associated with an increased morbidity and mortality rate in elderly population. As in one of the north London hospitals, an increase i...
Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma
airway hyperresponsiveness airway remodeling asthma murine model PDE inhibitor
2010/11/16
Background: Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling.
Objective: The aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 a...
The Effect of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole on the Cell Death Induced by Zinc Administration in the Brain of Rats
Zinc cell death hippocampus 7-nitroindazole stereology rat
2009/5/20
Aim: To evaluate the effect of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) on hippocampal cell loss induced by zinc hemisulfate salt (ZnSO4·7H2O) treatment. Materials an...
An Improved Mouse Model of Atopic Dermatitis and Suppression of Skin Lesions by an Inhibitor of Tec Family Kinases
allergen atopic dermatitis mite Tec Th2
2010/11/18
We established a highly efficient, highly reproducible protocol to induce skin lesions in NC/Nga mice and successfully applied it to show the efficacy of terreic acid in treating skin lesions. This mo...
A Case of Angioedema Associated with Decreased C1 Inhibitor Activity
Angioedema C1 inhibitor complement HAE triggering factor
2010/11/18
Background: We report a case of a 31-year-old woman who began to notice swelling of her arms at age 20. She was once given a diagnosis of cellulitis, but her symptoms spontaneously resolved. The patie...
The effects of genistein, a tyrosine kinase inhibitor on acute and chronic inflammation in diabetic mice
Diabetes Genistein Inflammation Mice Streptozotocin Tyrosine kinase
2010/2/3
The effects of tyrosine kinases on acute and chronic inflammation during diabetes are not fully determined. Therefore, the present study focuses on the effects of genistein, a tyrosine kinase inhibito...
Role of a Th2 cytokine inhibitor in asthma treatment
cough variant asthma eosinophilic airway inflammation interleukin-4 interleukin-5 interleukin-13 steroid-sparing effect
2010/11/22
The airway wall of asthmatic patients is infiltrated with inflammatory cells, consisting chiefly of eosinophils and T lymphocytes. Among these T lymphocytes, Th2 cells are involved in the regulation o...