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Inhibitory effect of calotropis gigantea extract on ovalbumin-induced airway inflammation and arachidonic acid induced inflammation in a murine model of asthma
arachidonic acid Calotropis gigantea ovalbumin
2015/7/21
The root of Calotropis gigantea has been reported as a traditional folkloric medicine in treatment of asthma in the Indian literature. Root contain α-and β-amyrin are reported to possess anti-lipoxyge...
Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis
Chemokine Receptor CCR9 Rheumatoid Arthritis Inflammation Antigen-Induced Arthritis Mouse Mod-el Monocytes/Macrophages
2013/1/31
Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone ...
Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma
airway hyperresponsiveness airway remodeling asthma murine model PDE inhibitor
2010/11/16
Background: Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling.
Objective: The aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 a...
Effects of Respiratory Syncytial Virus Infection on Dendritic Cells and Cysteinyl Leukotrienes in Lung Tissues of a Murine Model of Asthma
asthma cysteinyl leukotrienes dendritic cell Dermatophagoides farinae respiratory syncytial virus
2010/11/18
Background: Pulmonary dendritic cells (DCs) play critical roles in both allergy and in viral infection. Levels of cysteinyl leukotrienes (cysLTs) increase after allergen sensitization and viral infect...
The Distinctive Effects of Acute and Chronic Psychological Stress on Airway Inflammation in a Murine Model of Allergic Asthma
airway inflammation bronchial asthma opioid psychological stress μ-opioid receptor
2010/11/18
In BALB/c mice, but not in C57BL/6 mice, the number of total cells, eosinophils and lymphocytes in the acute stress group were significantly decreased compared with those in the non-acute stress group...
Subcutaneous Vaccination of Mycobacterium bovis Bacillus Calmette-Guérin Attenuates Allergic Inflammation in a Murine Model of Asthma
asthma CD4+ T cell chemokine Mycobacterium bovis Th1/Th2
2010/11/22
We found that BCG-vaccinated mice had fewer eosinophils in BALF and less severe allergic inflammation. The expression of IL-4 as well as Eotaxin and TARC was down-regulated in the vaccinated mice, whi...
Increased Levels of CTGF mRNA Expression in a Murine Model of Allergic Airway Inflammation
asthma collagen remodeling subepithelial fibrosis TGF-β
2010/11/19
Numbers of eosinophils and TGF-β1 concentration increased markedly in BALF on the 7th day and 14th day after inhalation challenge with OVA. Hydroxyproline content in lung tissue increased significantl...