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Background: Hepcidin is a key regulator of iron absorption in humans. It is mainly affected by hypoxia and iron stores.
Beta thalassemia major is a chronic hemolytic anemia because of abnormal hemoglobin synthesis. These patients are at risk for iron overload and tissue intoxication. Heart failure is the most common an...
The disease of thalassemia major requires mangement by repeated transfusions of packed cell and iron chelators such as deferoxamine. Today, serum ferritin is used for estimation of adequacy of the man...
Objective: In thalassemia major, extramedulary hematopoiesis results in bony deformities such as sever malocclusion in the head and neck, delayed pneumatization of paranasal sinuses and so on. Also, t...

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