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High Bone Mass in Mice Lacking Cx37 Due to Defective Osteoclast Differentiation
gap junctions connexin37 osteoclast
2014/11/6
Connexin (Cx) proteins are essential for cell differentiation, function and survival in all tissues with Cx43 being the most studied in bone. We now report that Cx37, another member of the connexin fa...
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice
podosome organization bone density osteoclast functions
2014/11/6
The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild osteopetrosis due to impairment in osteoclast ...
Soft-diet Feeding Inhibits Adult Neurogenesis in Hippocampus of Mice
Mastication Neurogenesis Neurotrophin
2010/1/21
Our previous study showed that mice fed on a soft diet after weaning had reduced levels of brain-derived neurotrophic factor (BDNF) protein in the hippocampus after 3 months of age compared with mice ...
Oral candidosis by Candida albicans in normal and xerostomic mice
Candidiasis oral Candida albicans Xerostomia
2009/10/20
The aim of this study was to analyze the effect of sialoadenectomy on the development of oral candidosis after one or four inoculations of Candida albicans. Initially, a suspension containing 108 cell...
Localization of Bmp-4, Shh and Wnt-5a transcripts during early mice tooth development by in situ hybridization
Odontogenesis Tooth germ Wnt proteins Bone morphogenetic proteins
2009/10/19
A comparative nonisotopic in situ hybridization (ISH) analysis was carried out for the detection of Bmp-4, Shh and Wnt-5a transcripts during mice odontogenesis from initiation to cap stage. Bmp-4 was ...
An M-CSF Receptor c-Fms Antibody Inhibits Mechanical Stress–Induced Root Resorption during Orthodontic Tooth Movement in Mice
c-Fms Odontoclast Root resorption Mouse Orthodontics
2010/3/5
Objective: To examine the effect of anti-c-Fms antibody on odontoclastogenesis and root resorption in an orthodontic tooth movement mouse model.
Materials and Methods: We used orthodontic tooth mov...
Soft-diet Feeding Inhibits Adult Neurogenesis in Hippocampus of Mice
Mastication Neurogenesis Neurotrophin
2010/12/1
Our previous study showed that mice fed on a soft diet after weaning had reduced levels of brain-derived neurotrophic factor (BDNF) protein in the hippocampus after 3 months of age compared with mice ...
Effects of Soft-diet Feeding on BDNF Expression in Hippocampus of Mice
Mastication Synaptogenesis Neurotrophin
2010/12/1
Our previous study showed that mice fed a soft diet after weaning had reduced synaptic connections in the hippocampal formation and impaired spatial learning ability after 3 months of age. We hypothes...
Expression of Notch1 and Math1 in Mandibular Condyle Cartilage in Neonatal Mice
Notch1 Math1 Osteopontin Mandibular condylar cartilage Immunohistochemistry
2008/12/4
On the basis of the cellular morphological changes in the cartilaginous area, the mandibular condylar cartilage is histopathologically composed of four different cell layers—fibrous, proliferative...
Temporal Expression of SOX9 and Type II Collagen in Spheno-Occipital Synchondrosis of Mice after Mechanical Tension Stimuli
Spheno-occipital synchondrosis SOX9 Type II collagen Tensile stress Cartilage
2008/10/29
Objective: To associate the expressions of SOX9 and type II collagen during growth in the synchondrosis with and without tensile stress in order to understand the role of these factors in the growth o...
Effect of the maternal environment on cortisone-induced cleft palate in mice
Cleft palate Cortisone Maternal environment effect Mou
2008/4/19
OBJECTIVE: To investigate the maternal environment influence on cortisone-induced cleft palate in mice. METHODS: The A/WySn and the C3H/He strains of mice were used. Pregnant mice were injected on day...
Effect of tube feeding on hippocampal-dependent memory in SAMP1 mice
Fos Hippocampus SAMP1 Spatial memory Tube feeding
2008/4/19
This study examined the effect of tube feeding on hippocampal Fos induction and spatial performance in a water maze task in senescence-accelerated mice (SAMP1). Tube feeding accelerated the age-relate...
Genetic mapping of fused root of the maxillary second molar in mice to chromosome 5
Fused root Inbred mice Linkage analysis
2008/4/17
Although studies have identified several genes that are involved in tooth root formation, little is known about the genetics of root fusion. The purpose of the present study was to identify the chromo...
Identification of chromosomal region(s) influencing initial dental caries susceptibility in mice
Inbred mouse Initial dental caries QTL analysis Quantitative gene(s) Streptococcus mutans
2008/4/17
Predicting the host genetic factors influencing dental caries susceptibility is important to developing preventive strategies in individuals. In this study, Quantitative Trait Locus (QTL) analysis was...
Detection of informative markers for searching a causative gene(s) of cleft lip with palate in A/WySn mice
A/WySn mice C3H/He mice Cleft lip with palate Mit marker
2008/4/16
Cleft lip with palate is a widespread disfiguring birth defect of complex and poorly understood etiology. The A/WySn mice are good models with which to study the genetic factors of cleft. Our previous...