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2019年11月13日，浙江大学医学院附属口腔医院王慧明教授团队在STEM CELLs（干细胞领域权威期刊之一）上在线发表题为“KLF2+ stemness maintains human mesenchymal stem cells in bone regeneration”的研究论文，首次提出采用KLF2作为人骨髓间充质干细胞(hMSCs)体外标志物，并研究KLF2+hMSCs在血管再生和骨组...
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
autocrine signaling bone marrow cells breast cancer
2014/11/6
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB...
The cytomorphological analysis of buccal mucosa cells in smokers
Oral exfoliative cytology cytomorphometry smoking buccal mucosa
2011/3/22
To examine the effect of smoking on normal buccal mucosa cytomorphologically. Materials and methods: Forty individuals aged between 40 and 60, comprising 23 smokers (14 male, 9 female) and 17 and non-...
Fluoride does not induce DNA breakage in Chinese hamster ovary cells in vitro
Sodium fluoride Comet assay Mutagenicity tests
2009/10/20
Fluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing inju...
Adherence to HeLa cells, typing by killer toxins and susceptibility to antifungal agents of Candida dubliniensis strains
Candida Cell adhesion Acquired immunodeficiency syndrome HIV
2009/10/16
The aim of this study was to evaluate the adherence capability to HeLa cells, the susceptibility to killer toxins and the in vitro susceptibility to antifungal agents (eTest? method - AB Biodisk, Soln...
Interstitial and Langerhans' dendritic cells in chronic periodontitis and gingivitis
Periodontitis Gingivitis Dendritic cells CD1a Factor XIIIa
2009/10/16
The aim of the present study was to compare quantitatively the distribution of dendritic cell subpopulations in chronic periodontitis and gingivitis. Fourteen biopsies from patients with chronic perio...
Induction of TGF-β and BMP-2 by Simvastatin in Human Periodontal Ligament Cells
simvastatin human periodontal ligament (HPDL) cells transforming growth factor-β1 (TGF-β1) bone morphogenetic protein-2 (BMP-2)
2009/5/21
Statins, which are highly effective cholesterol-lowering drugs, induce bone morphogenetic protein (BMP)-2 expression. However, the other growth factors except for BMP-2 and the effects of statins on p...
Expression of the osteoblastic marker in human alveolar bone cells spheroid
human alveolar bone cell periodontal tissue regeneration cell sheet graft immunohistochemical staining
2009/5/20
We previously reported the presence of type I, and III collagen (Col-I, III) and proliferating cells in human alveolar bone cells (HABCs) three-dimensional (3D) grafts (spheroid). The existence and d...
Novel Preparation of Grafts Composed of Human Alveolar Bone Periosteal Cells
human alveolar bone periosteal cell periodontal tissue regeneration cell sheet graft immunohistochemical staining
2009/5/20
We studied the possibility of using grafts composed of human alveolar bone periosteal cells (HABPCs) for periodontal regeneration. HABPCs were inoculated four times to become a multilayer cell sheet e...
Effects of Cyclic Tension Force on Differentiation in Human Periodontal Ligament Cells
mechanical stress differentiation human periodontal ligament (HPDL) cell periostin Twist
2009/5/20
The periodontal ligament is exposed to mechanical stress such as occlusion, so periodontal ligament cells may have defenses against mechanical stress. We searched for the influence of mechanical stres...
Gene Expression Analysis of Chronically Inflamed and Healthy Human Periodontal Ligament Cells in vivo
Gene Expression Analysis Healthy Human Periodontal Ligament Cells
2009/4/2
Gene Expression Analysis of Chronically Inflamed and Healthy Human Periodontal Ligament Cells in vivo.
Morphohistological Change and Expression of HSP70, Osteopontin and Osteocalcin mRNAs in Rat Dental Pulp Cells with Orthodontic Tooth Movement
Tooth movement HSP70 Osteopontin Osteocaclin
2010/12/1
Morphological change and expression of osteopontin, osteocalcin, and HSP70 mRNAs in rat dental pulp cells with experimental orthodontic tooth movement were investigated. Elastic rubber blocks, 0.65 mm...