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Mechanism of LHRH-stimulated steroidogenesis in rat Leydig cells：lipoxygenase products of arachidonic acid may not be involved
LHRH-stimulated steroidogenesis rat Leydig cells lipoxygenase products arachidonic acid
2009/2/23
Luteinizing hormone releasing hormone agonist, [(imBzl)-DHis6,Pro9,NEt]-LHRH (LHRH-A), caused a two to threefold increase in in vitro testosterone (T) secretion by rat Leydig cells. This LHRH-A-indu...
Mechanism of action of gonadotropin-releasing hormone-stimulated Leydig cell steroidogenesis. II. Gonadotropin-releasing hormone stimulates phospholipid labeling
gonadotropin-releasing hormone Leydig cells steroidogenesis phospholipids
2009/2/20
To investigate mechanisms responsible for gonadotropin-releasing hormone (GnRH)-stimulated Leydig cell steroidogenesis, the effects of GnRH agonist [des-Gly10, (D-Ala6) GnRH] on phospholipid turnove...
Mechanism of action of gonadotropin-releasing hormone-stimulated Leydig cell steroidogenesis
gonadotropin-releasing hormone Leydig cells testosterone cAMP cAMP-dependent protein kinase nifedipine calcium
2009/2/20
The present study was designed to elucidate mechanisms responsible for gonadotropin-releasing hormone (GnRH)-stimulated testosterone formation. Purified Leydig cells from adult Sprague-Dawley rats...
On the Mechanism for Flow in the Efferent Ducts
efferent ducts peristalsis cilia fluid flow mathematical model
2009/2/18
A cilio-peristaltic model for pumping of efferent duct (ED) contents that predicts the observed volumetric flow rates and is consistent with a positive pressure gradient toward the epididymis is pro...
Testosterone decreases 3beta-hydroxysteroid dehydrogenase-isomerase messenger ribonucleic acid in cultured mouse Leydig cells by a strain-specific mechanism
Steroidogenesis testis inbred mice androgen
2009/2/17
We previously reported a strain-related difference in basal 3beta-hydroxysteroid dehydrogenase-isomerase (3betaHSD) activity in response to testosterone in cultured Leydig cells. The data suggested ...
Mechanism of stress-induced attenuation of the testicular response to gonadotropin：possible involvement of testicular opioids, a pertussis toxin-sensitive G-protein, and phosphodiesterase
stress-induced attenuation possible involvement testicular opioids pertussis toxin-sensitive G-protein
2009/2/16
This study examined the potential role of testicular opioids, a pertussis toxin (PT)-sensitive G-protein, and phosphodiesterase in mediating the inhibitory effect of immobilization stress on testi...
Mechanism of superoxide dismutase loss from human sperm cells during cryopreservation
superoxide dismutase loss human sperm cells cryopreservation
2009/2/12
Earlier studies on human sperm cryodamage have shown that plasma membrane stress is the primary process and that phospholipid peroxidation in cryopreserved samples is not inhibited by addition of an...
Mechanism of protection of rat spermatogenesis by hormonal pretreatment：stimulation of spermatogonial differentiation after irradiation
Mechanism protection rat spermatogenesis hormonal pretreatment stimulation irradiation
2008/12/25
Pretreatment of rats with hormones that suppress testosterone levels and sperm production enhances the recovery of spermatogenesis from stem cells after a cytotoxic insult. It is not known whether t...
Acrosome Reaction Induced by Recombinant Human Zona Pellucida 3 Peptides rhuZP3a22176 and rhuZP3b177348 and Their Mechanism
Human sperm pertussis toxin intracellular calcium G protein calcium channel chlortetracycline
2008/12/24
To explore the biological characteristics of the recombinant zona pellucida 3 (ZP3) peptides of rhuZP3a22176 and rhuZP3b177348, we examined whether rhuZP3a22176 or rhuZP3b177348 trigger the acros...
Role of Oxidative Stress in the Pathophysiological Mechanism of Erectile Dysfunction
Oxidative Stress Pathophysiological Mechanism Erectile Dysfunction
2008/12/24
Erectile dysfunction (ED) is defined as the inability to achieve or maintain erections sufficient for satisfactory sexual intercourse (NIH Consensus Conference, 1993). It is estimated that the pre...
Adipocyte Accumulation in Penile Corpus Cavernosum of the Orchiectomized Rabbit: A Potential Mechanism for Veno-occlusive Dysfunction in Androgen Deficiency
Trabecular smooth muscle veno-occlusion fat-containing cells
2008/12/23
Androgens are deemed to be critical for the development, growth, and maintenance of penile tissue as well as for erectile function. Androgens are also reported to inhibit differentiation of stroma p...