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Impaired germ cell development in the testes of immature rats with neonatal hypothyroidism
Gonocyte Sertoli cell thyroid hormone stereology optical disector germ cell number
2009/2/17
The induction of neonatal hypothyroidism from day 1 to day 25 postpartum using 6-propyl-2-thiouracil (PTU) resulted in a 45% and 77% reduction of testis weight on days 20 and 30, respectively, and a...
Increased proliferation of Leydig cells induced by neonatal hypothyroidism in the rat
Propylthiouracil goitrogen cell kinetics ontogeny mitosis puberty
2009/2/16
Treatment of male rat pups with the reversible goitrogen 6-n-propyl-2-thiouracil (PTU), administered by adding 0.1% PTU to the mother's drinking water from birth through weaning, increases adult t...