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Presence and modulation of interleukin-12 in seminal plasma of fertile and infertile men
Cytokines interleukins infertility semen
2009/2/17
Interleukin-12 (IL-12) is a unique cytokine that recently has drawn considerable attention because of its immunomodulatory properties and its possible involvement in several normal physiological a...
Secretion of bioactive interleukin 1 by rat testicular macrophages in vitro
Cytokines bioassay immunoregulation IL-i receptor antagonist testosterone
2009/2/16
The relative capacities for testicular macrophages and resident peritoneal macrophages to secrete the pro-inflammatory cytokine, interleukin 1 (LL-1), in response to stimulation by bacterial lipop...
Interleukin-6 enhances the fertilizing capacity of human sperm by increasing capacitation and acrosome reaction
Interleukin-6 enhances human sperm acrosome reaction
2009/2/12
The effects of human recombinant interleukin-6 (IL-6) on human sperm penetration of zona-free hamster ova (SPA) and human sperm cell capacitation and acrosome reaction were investigated. IL-6 at h...
Increased levels of interleukin-6 in seminal plasma of infertile men
Increased levels interleukin-6 seminal plasma infertile men
2009/2/12
The presence of various cytokines, namely the tumor necrosis factor (TNF-alpha), interferon (IFN-gamma), and interleukins (IL-1 beta and IL-6), was investigated in seminal plasma of fertile, infer...
Direct and indirect effects of murine interleukin-2, gamma interferon, and tumor necrosis factor on testosterone synthesis in mouse Leydig cells
murine interleukin-2 gamma interferon tumor necrosis factor testosterone synthesis
2009/2/11
It was recently observed that treatment of patients with a high dosage of human interleukin (IL-2) resulted in suppression of plasma concentrations of testosterone. A murine model was developed to a...
Human interleukin-1 alpha crosses the blood-testis barriers of the mouse
Cytokine Sertoli cell transport blood-brain barrier germinal cells
2009/2/10
Interleukin-1 alpha (IL-1 alpha) has been shown to have direct effects on the gonads, affecting steroidal secretion, DNA synthesis by spermatogonia, and the immune function of the testes. It is un...
The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro
Tumor necrosis factor interleukin-1 interferon human sperm motility
2009/2/10
Whether cytokines present in human peritoneal fluid reduce sperm motility, and thus contribute to infertility, is investigated. The human recombinant cytokines, tumor necrosis factor-alpha, interl...
Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro
umor necrosis factor interleukin-1 testis testosterone
2009/2/6
The actions of two cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), on testosterone production by dispersed adult testis cells and purified Leydig cells in culture were studied. In o...
Interleukin-1beta regulates nitric oxide production and gamma-glutamyl transpeptidase activity in sertoli cells
nitric oxide production gamma-glutamyl transpeptidase activity sertoli cells
2008/12/25
Several cytokines have been involved in the regulation of Sertoli cell function. Further investigations are required to elucidate the role of interleukin-1beta (IL1beta) in Sertoli cell physiology. ...