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CORRELATING IRINOTECAN AND CAPECITABINE TREATMENT FOR COLORECTAL CANCER TO GENE EXPRESSION, POLYMORPHISMS, AND CLINICAL OUTCOMES
Irinotecan CPT-11 Capecitabine
2015/5/25
Colorectal cancer is the third most common type of cancer and the third most common cause of cancer-related mortality. There are three types of treatment available to patients, either individually or ...
Recent advances in anti-cancer treatment have seen improvements in survival for patients with metastatic colorectal cancer. Increasingly, patients with advanced disease are living longer, sometimes wi...
Colonoscopy has a central role in the detection and prevention of colorectal cancer. This is based on the fact that most colorectal cancer develops from premalignant adenomatous or serrated polyps, wh...
Surgery is the mainstay in the treatment of colorectal cancer. Considerable progress has been made in the past eight years since the publication of the most recent clinical practice guidelines for col...
Patients with resected colon cancer (stage III [T1 to T4, N1-N2] or high-risk stage II [T3 or T4, N0]) or stage II/III rectal cancers (T3 or T4, N0-2) are at significant risk of local and distant fail...
Targeting treatment for colorectal cancer: the EGFR antibody story
Targeting treatment colorectal cancer
2015/4/13
Frequent overexpression of the epidermal growth factor receptor in colorectal cancer was the rationale for the development of anti-epidermal growth factor receptor antibodies. The development of the d...
Risk profiling and surveillance: previous adenomas and colorectal cancer
previous adenomas colorectal cancer
2015/4/13
The brief of this issue of Cancer Forum is to review information available since the 2005 publication of the National Health and Medical Research Council relating to risk management of individuals wit...
Familial cancer clinics strive to identify at-risk individuals with an inherited predisposition to cancer. Familial predisposition to colorectal cancer includes Familial Adenomatous Polyposis and Lync...
Family history of colorectal cancer is a well-established and consistently strong risk factor for this disease. However, simply counting the number of affected relatives is an imprecise measure of col...
Screening for colorectal cancer – new evidence in the last 10 years
colorectal cancer new evidence
2015/4/13
The evidence base for screening for colorectal cancer has expanded at a rapid pace in the last 10 years. Faecal immunochemical tests for haemoglobin have been proven to be superior to guaiac-based fae...
Colorectal cancer is the third most common type of cancer worldwide, with the highest incidences in Australia, New Zealand, Europe and North America, and the lowest in Africa and South-Central Asia. R...
Keeping abreast of the evidence in management of colorectal cancer
management colorectal cancer
2015/4/13
The opportunity to host as Guest-Editor this issue
of Cancer Forum, has indeed been timely. The
unannounced rescindment by the National Health
and Medical Research Council’s Guideline of the
P...
Major advances in the prevention, diagnosis and both curative and palliative management of colorectal cancer
have occurred in the past 40 years. Australian clinicians have been at the forefront thro...
Our understanding of the molecular pathways that mediate cancer cell proliferation has increased significantly and with
this comes the rapid development of molecular targeted therapies. The epidermal...
Discriminating factors in treatment decisions for chemotherapy in elderly patients with colorectal cancer
Discriminating factors treatment decisions
2015/3/26
Chemotherapy is underutilised in patients over the age of 70 and good arguments exist to support active treatment in this group. We examined patient and disease factors in colorectal cancer patients a...