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Deep dive into key COVID-19 protein is step toward new drugs, vaccines（图）
COVID-19 protein step toward new drugs vaccines
2021/4/23
Researchers at Oregon State University have taken a key step toward new drugs and vaccines for combating COVID-19 with a detailed biophysical study of one protein's interactions with the SARS-CoV-2 ge...
Key Residues of the Receptor Binding Motif in the Spike Protein of SARS-CoV-2 That Interact With ACE2 and Neutralizing Antibodies
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotens...
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells
SARS-CoV-2-encoded nucleocapsid protein acts viral suppressor of RNA interference cells
2020/6/12
We thank Prof. Peng Zhou (Wuhan, China) for kindly providing materials and thank Yan Wu and Weijuan Shang for experimental assistance. This work was supported by the Strategic Priority Research Progra...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
Fusion mechanism 2019-nCoV inhibitors targeting HR1 domain spike protein
2020/6/12
Very recently, a novel coronavirus, 2019-nCoV, emerged in Wuhan, China and then quickly spread worldwide, resulting in >17,388 confirmed cases and 361 deaths as of 3 February 2020, thus calling for th...
Dietary protein, carbohydrate, and fat enhance memory performance in the healthy elderly
Glucose carbohydrate protein
2016/6/14
Dietary carbohydrates can improve memory.
Whether these effects are related to elevations in blood glucose
or to energy ingestion is unknown.
Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men
Obesity leptin OB protein
2016/6/14
Results of leptin administration in mice, rats, and
humans provide a rationale for therapeutic augmentation of circulating
leptin (OB protein) concentrations in obese humans;
this may reduce food i...
High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function
uric acid cardiovascular disease creatinine
2016/6/14
The metabolic effects of diets high in vegetable
protein have not been assessed despite much recent interest in
the effect of soy proteins in reducing serum cholesterol.
Treatment of protein-energy malnutrition in chronic nonmalignant disorders
chronic renal failure rheumatoid arthritis elderly
2016/6/14
Protein-energy malnutrition (PEM) is common
in connection with chronic disease and is associated with
increased morbidity and mortality. Because the risk of PEM is
related to the degree of illness,...
The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women
Soy protein isoflavones LDL cholesterol
2016/6/13
Clinical trial data and the results of a meta-analysis
suggest a hypocholesterolemic effect of soy protein. The effect
may be partially attributable to the isoflavones in soy. Few studies
have exam...
Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A–deficient children from the Republic of the Marshall Islands
retinol retinol binding protein RBP
2016/6/13
Serum retinol is transported by retinol binding protein
(RBP), which has one high-affinity binding site for retinol;
consequently, the molar ratio of retinol to RBP in the circulation
is 1 to 1. In...
A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women
Diet protein bone mineral density
2016/6/12
Different sources of dietary protein may have different
effects on bone metabolism. Animal foods provide predominantly
acid precursors, whereas protein in vegetable foods
is accompanied by base pre...
Protein intake and bone health: the influence of belief systems on the conduct of nutritional science
Protein intake bone health
2016/6/12
It was first shown nearly 80 y ago, and has been confirmed
many times since, that ingestion of protein increases urinary
calcium excretion. Most such work involved isolated protein
feedings, and qu...
Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis–derived endogenous glutamine production
Glutamine glutamic acid muscles
2016/6/1
Results of tracer studies indicate that skeletal muscle
contributes to <70% of overall glutamine production in
healthy adults; the contribution of de novo synthesis being estimated
at <60%. However...