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We previously showed that mortality from infectious diseases among young adults in rural Gambia is strongly correlated with the season of their birth. This suggests that early life insults that inv...
The aging process can lead to a decline in cellular immunity. Therefore, the elderly could benefit from safe and effective interventions that restore cellular immune functions.
The role of single micronutrient deficiencies in the etiology of growth retardation has recently gained attention. However, because multiple micronutrient deficiencies are common in children in dev...
Zinc deficiency is thought to be common in young children in developing countries and some data suggest that it may detrimentally affect children’s development.
Zinc deficiency may result in abnormal dark adaptation or night blindness, a symptom primarily of vitamin A deficiency. During a placebo-controlled trial in Nepal, weekly vitamin A supplementation ...
The serum total homocysteine concentration (tHcy), an indicator of folate status and a possible risk factor for vascular disease, is elevated with impaired renal function and poor vitamin B-12 stat...
Animal studies showed that dietary flaxseed oil [rich in the n3 polyunsaturated fatty acid -linolenic acid (ALA)], evening primrose oil [rich in the n6 polyunsaturated fatty acid -linolenic acid (...
A key aim when conducting systematic reviews of randomized controlled trials (RCTs) is to include all of the evidence, if possible. Serious bias may result if trials are missed through inadequate s...
The digestibility of cocoa butter was reported in animal but not human studies to be low (60–70% and 89–94%, respectively). These differences could be due to the much higher ratio of calcium to fat...
Oxidative stress is increased in patients with congestive heart failure and can contribute to the progressive deterioration observed in these patients. Increased oxidative stress is the result of e...
Treatment of phenylketonuria (PKU) consists of restriction of natural protein and provision of a protein substitute that lacks phenylalanine but is enriched in tyrosine. Large and unexplained diffe...
We have shown that the age-associated increase in prostaglandin E2 production contributes to the decline in T cellmediated function with age. Black currant seed oil (BCSO), rich in both g-linoleni...
Lycopene has been identified as a phytochemical with potentially protective health benefits.
The food matrix in which carotenoids are found affects their bioavailability. Lutein and zeaxanthin are abundant in egg yolks and accumulate in the macular region of the retina, where they may affe...

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