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Effect of compression rate on HPNS convulsion threshold in the euthermic rat
high pressure nervous syndrome compression rate animal rat
2009/7/20
The modification of the development of the high pressure nervous syndrome (HPNS) has been demonstrated by varying the external environment (chamber temperature, compression rate) or the internal envir...
Cerebellar and cerebral electroencephalogram during the high pressure nervous syndrome (HPNS) in rats
high pressure nervous syndrome electroencephalogram animal rat seizures
2009/7/20
Electroencephalographic activity of the frontal cortex, cerebellar vermis, and superior vestibular nucleus was recorded in awake rats during the high pressure nervous syndrome (HPNS) by means of perma...
Quantification of high pressure nervous syndrome (HPNS) tremor in the guinea pig
hyperbaric high pressure nervous syndrome tremor animal guinea pig
2009/7/20
Previous studies have demonstrated two tremorgenic systems that involve separate brain mechanisms and exhibit different peak frequencies. One system (the thalamo-cortical) generates low frequency (4--...
Effect of helium/nitrogen/oxygen mixtures on HPNS convulsion threshold in euthermic rats
high pressure nervous syndrome trimix convulsion animal rat seizures heliox
2009/7/17
This study compares the effects of various so-called trimix mixtures (10, 20, and 40 percent N2 in He-O2) on the convulsion threshold pressure (Pc) and EEG activity in 60 adult male Wistar rats with c...
HPNS during rapid compressions of men breathing He-O2 and He-N2-O2 at 300 m and 180 m
human high pressure nervous syndrome heliox trimix compression Tremor
2009/7/17
HPNS during rapid compressions of men breathing He-O2 and He-N2-O2 at 300 m and 180 m.
Lithium effects:protection against nitrogen narcosis, potentiation of HPNS
nitrogen narcosis high pressure nervous syndrome Lithium drug
2009/7/17
The effect of either 10, 8, or 6 meq/kg of intraperitoneal lithium chloride or sodium chloride on the loss of righting response (RR50) produced by 18.2 ATA N2-ATA O2 was examined in rats. Results were...
Control of HPNS in humans during rapid compression with trimix to 650 m (2131 ft)
human trimix HPNS high pressure nervous syndrome rapid compression
2009/7/16
In 1978 a series of deep trimix (He-N2-O2) dives was initiated to establish the relationship between a given nitrogen percentage and the rate of compression required to prevent the high pressure nervo...
Effect of compression rate on use of trimix to ameliorate HPNS in man to 686 m (2250 ft)
decompression human compression rate trimix high pressure neurologic syndrome heliox Psychological Psychomotor Performance
2009/7/16
Previous man dives, in a series designed to evaluate the physiological effects of helium, nitrogen, and oxygen (trimix), investigated the comparative effects of 5 percent vs. 10 percent nitrogen with ...
Effects of variations in time pattern of nitrogen addition on development of HPNS in mice
drug high pressure nervous syndrome animal mice heliox trimix
2009/7/16
The effect of change in injection pattern in nitrogen on threshold pressures of three symptoms associated with compression in helium/nitrogen atmospheres was explored. Excitement threshold pressures d...
Use of EEG digital filtering and display for HPNS diagnosis
decompression human high pressure nervous syndrome
2009/7/14
Divers show symptoms of a condition known as the high pressure nervous syndrome (HPNS) at depths greater than about 180 m. A symptom that possibly lends itself to an objective diagnosis is a change in...
Effect of benzazole-related centrally acting muscle relaxants on HPNS
benzazole high pressure nervous syndrome animal mice
2009/7/14
A series of benzazole-related, centrally acting muscle relaxants, comprising benzimidazole, chlorzoxazone, and zoxazolamine, were found to give substantial protection against the tremors and convulsio...
Effects of a H2-He-O2 mixture on the HPNS up to 450 msw
hydrogen high pressure nervous syndrome
2009/7/9
A H2-He-O2 mixture with 54 to 56% hydrogen was studied with 6 subjects (professional divers) during 2 dives to 450 m. The 38-h compression was the same as that used with other types of breathing mixtu...
HPNS effects among 18 divers during compression to 360 msw on heliox
cognitive high pressure neurologic syndrome compression heliox
2009/7/9
Heliox compression deeper than 16 ATA can lead to EEG changes associated with confusion and somnolence. In man the symptoms termed the high pressure neurologic syndrome (HPNS) can also include increas...
Sodium valproate interactions with the HPNS: EEG and behavioral observations
animal baboon model hyperbaric chamber high pressure nervous syndrome
2009/7/9
A new baboon model was used to investigate the therapuetic effect of sodium valproate on the high pressure neurologic syndrome (HPNS). A hyperbaric chamber was used to achieve environmental pressures ...
Effects of four drugs on 4-aminopyridine seizures: a comparison with their effects on HPNS
hyperbaric high pressure nervous syndrome drug
2009/7/8
The effects of two i.v. anesthetics, Saffan and methohexitone (MHX) and two N-methyl-D-aspartate receptor antagonists, MK-801 (Dizocilpine) and 2-aminophosphonoheptanoate (AP7), were tested for activi...