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Tyrosine requirement of healthy men receiving a fixed phenylalanine intake determined by using indicator amino acid oxidation
stable isotopes adult amino acid requirements Amino acid metabolism
2016/6/12
The currently accepted total aromatic amino acid
requirement for adults is based on nitrogen balance measurements
in individuals who received their intake of aromatic amino
acids solely as phenylal...
Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets
Phenylketonuria PKU tyrosine
2016/6/12
Treatment of phenylketonuria (PKU) consists
of restriction of natural protein and provision of a protein substitute
that lacks phenylalanine but is enriched in tyrosine. Large
and unexplained diffe...
Putative Hydrogen Bond to Tyrosine M208 in Photosynthetic Reaction Centers from Rhodobacter capsulatus Significantly Slows Primary Charge Separation
Coagulation Nano TiO2 Nano Al2O3 Breakage Fractal dimension
2016/5/25
Slow, ～50 ps, P* → P(+)HA(-) electron transfer is observed in Rhodobacter capsulatus reaction centers (RCs) bearing the native Tyr residue at M208 and the single amino acid change of isoleucine at M20...
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
Tyrosine Ingestion and Its Effects on Cognitive and Physical Performance in the Heat
HEAT STRESS CENTRAL FATIGUE AMINO ACIDS
2017/4/13
Purpose: Ingestion of tyrosine (TYR), a catecholamine precursor, has previously improved aspects of cognitive function and mood during acute stress, although there is limited research exploring the op...
Functional Insights Into Oncogenic Protein Tyrosine Phosphatases By Mass Spectrometry
Protein Tyrosine Phosphatases Mass Spectrometry
2015/5/25
Phosphatase of Regenerating Liver 3 (PRL3) is suspected to be a causative factor toward cellular metastasis when overexpressed. To date, the molecular basis for PRL3 function remains an enigma, justif...
Tyrosine Phosphorylation Events in Mouse Sperm Capacitation
Tyrosine Phosphorylation Events Mouse Sperm
2014/10/23
Mammalian sperm are not able to fertilize immediately upon ejaculation; they become fertilization-competent after undergoing changes in the female reproductive tract collectively termed capacitation. ...
Failure of Oral Tyrosine Supplementation to Improve Exercise Performance in the Heat
AMINO,ACIDS CATECHOLAMINES MILD,HYPERTHERMIA CENTRAL FATIGUE PROLONGED,EXERCISE
2017/5/23
Acute oral tyrosine administration has been associated with increased constant-load, submaximal exercise capacity in the heat. This study sought to determine whether self-paced exercise performance in...
Expression and Function of the PRL Family of Protein Tyrosine Phosphatase
PRL phosphatase PTP4A DSP cancer
2015/5/22
The PRL family of enzymes constitutes a unique class of protein tyrosine phosphatase, consisting of three highly homologous members (PRL-1, PRL-2, and PRL-3). Family member PRL-3 is highly expressed i...
Tyrosine kinase receptor B isoforms alter APP and BACE1 endogenous levels independently of BDNF
TrkB Alzheimer BACE1 SHC NFAT
2013/1/28
Brain derived neurotrophic factor (BDNF) levels and signaling via the tyrosine receptor kinase B (TrkB) have been shown to be altered in Alzheimer’s Disease. In addition, it has been reported that the...
Description of a Putative Oligosaccharyl:S-Layer Protein Transferase from the Tyrosine O-Glycosylation System of Paenibacillus alvei CCM 2051T
Bacterial Glycosylation S-Layer Oligosaccharyl Transferase
2013/1/29
Surface (S)-layer proteins are model systems for studying protein glycosylation in bacteria and simultaneously hold promises for the design of novel, glyco-functionalized modules for nanobiotechnology...
Expression of Neurotrophin 4 and Its Receptor Tyrosine Kinase B in Reproductive Tissues during the Follicular and Luteal Phases in Cows
Cows Neurotrophin 4 Tyrosine Kinase B Follicular Phase Luteal Phase Expression
2016/5/6
The neurotrophins, required for the survival and differentiation of the nervous system, are known to be important for the development of the reproductive tissues. However, the signals initiating the g...
The Effects of Phenoxybenzamine on Tyrosine Hydroxylase (TH) and TH mRNA Level in Adrenal Medulla of Sprague Dawley Rats
Phenoxybenzamine tyrosine hydroxylase adrenal medulla TH mRNA
2009/7/6
The effects of anti-hipertensive phenoxybenzamine were in-vestigated on tyrosine hydroxylase (TH) enzyme activity and TH mRNA levels. In the present study 5 months male sprague dawley (SD) rats were u...
Fms-like tyrosine kinase (Flt)-4 signaling participates in osteoclast differentiation in osteopetrotic (op/op) mice
Fms-like tyrosine kinase (Flt)-4 osteoclast differentiation osteopetrotic (op/op) mice
2009/5/8
Vascular endothelial growth factor (VEGF) induces osteoclast differentiation as well as neovascularization by binding to the fms-like tyrosine kinase (Flt)-1 and fetal liver kinase (Flk)-1 receptors...
目的：探讨血管生成素-1（Ang-1）对人脐静脉内皮细胞（HUVECs）内游离镁离子浓度（［Mg2+］i）的调节机制。方法:我们采用荧光指示剂mag-fura-2，运用PTi 阳离子测定系统动态测HUVECs的［Mg2+］i。结果:Ang-1诱导的［Mg2+］i增加与细胞外Mg2+浓度无关。Ang-1诱导的［Mg2+］i增加与细胞内Ca2+浓度无关。经酪氨酸激酶阻断剂(tyrphostin A23...