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滇产刺果番荔枝种子中的acetogenin类化合物
番荔枝科 刺果香荔枝 刺果番荔枝丁素
2009/4/20
刺果番荔枝（Annona muricata Linn.）为番荔枝科植物。西双版纳地区有栽培，为寻找其生理活性成分，我们对该植物种子进行化学成分分析，从中分到若干具有抗肿瘤活性的acetogenins类化合物。前文（Li et al，1994）已报道其中的 4个化合物。本文报道另外 2个 acetogenin衍生物。经风干粉碎的 3.5 kg刺果香荔枝种子，石油醚脱脂，然后用乙醇于室温下浸提，所得乙...
Synthesis of 13C-Labeled Ubiquinone-Acetogenin Hybrid Inhibitors of Mitochondrial Complex I
mitochondrial complex I acetogenin ubiquinone
2009/3/6
Natural acetogenins are the most potent inhibitors of mitochondrial complex I. By synthesizing a ubiquinone-acetogenin hybrid inhibitor (named Q-acetogenin), we previously showed that a γ-lactone ri...
Synthesis of photolabile Δlac-acetogenin for photoaffinity labeling of mitochondrial complex I
complex I acetogenin respiratory inhibitor
2009/3/5
Δlac-Acetogenins are a novel type of inhibitor acting at the terminal electron transfer step of mitochondrial NADH-ubiquinone oxidoreductase (complex I). To identify the binding site of Δlac-acetogeni...