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A plant-based, oral delivery of insulin regulates blood sugar levels similar to natural insulin（图）
Research Dental Medicine 天然胰岛素
2023/6/27
Insulin production has, for the last 50 or so years, come with some risks to the patient. Even so, the medication is lifesaving for the estimated 537 million adults living with diabetes worldwide, wit...
New method tracking changes in blood vessels could advance brain disease detection（图）
血管变化 脑部疾病 成像技术 神经退行性疾病
2023/6/26
A new imaging technique opens a path toward long-term study of blood vessels in aging brains and could help predict neurodegenerative diseases decades before symptoms begin.
Different cell types—say, heart, liver, blood, and sperm cells—possess characteristics that help them carry out their unique jobs in the body. In general, those characteristics are hard-wired. Without...
浙江大学生命科学学院陈才勇团队在Blood上发文揭示红细胞铁代谢重要调控机制（图）
陈才勇 红细胞铁代谢 单核苷酸
2022/10/12
红细胞是人体数量最多的一类细胞，其在成熟过程中需要吸收大量铁离子以用于合成血红素和血红蛋白。转铁蛋白（Tf）循环是红细胞以及其它很多类型细胞吸收铁离子的主要通路。在Tf循环中，细胞膜上的转铁蛋白受体（Tfrc）结合带铁的Tf后通过内吞作用进入细胞，释放铁离子，然后Tf-Tfrc复合体通过再循环内体回到细胞膜，因此该循环涉及Tfrc在细胞膜、初级内体和再循环内体之间的反复循环。为了快速吸收铁离子，红...
Engineers develop nanoparticles that cross the blood-brain barrier（图）
血脑屏障 纳米颗粒 胶质母细胞瘤 化疗药物
2023/6/19
There are currently few good treatment options for glioblastoma, an aggressive type of brain cancer with a high fatality rate. One reason that the disease is so difficult to treat is that most chemoth...
2022年2月19日，上海交通大学医学院刘俊岭教授团队樊雪梅副研究员等在Blood上发表了题为Inhibition of LDHA to Induce EEF2 Release Enhances Thrombocytopoiesis的文章。该项研究首次揭示了乳酸脱氢酶A（LDHA）在巨核细胞分化和血小板生成中的重要作用，并提示靶向LDHA与真核翻译延伸因子2（eEF2）的相互作用可以用于治疗血小板...
While neurons and glial cells are by far the most numerous cells in the brain, many other types of cells play important roles. Among those are cerebrovascular cells, which form the blood vessels that ...
近日，基础医学院郑俊克研究员课题组在血液领域国际著名期刊Blood在线发表了题为“Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches”的研究论文。
From counting blood cells to motion capture, sensors drive patient-centered research（图）
计数血细胞 动作捕捉 传感器
2023/6/8
Sensors and sensing systems — from devices that count white blood cells to technologies that monitor muscle coordination during rehabilitation — can positively impact medical research, scientists said...
基础医学院生物化学与分子细胞生物学系的副研究员马皎博士等最近在Blood杂志上发表了“Oncogenic role of SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2 positive diffuse large B cell lymphomas”的研究论文。报道了在一种染色体转位突变形成IGH-BCL2融合基因的大B细胞淋巴瘤（DLB...
Innovative coating for blood vessels reduces rejection of transplanted organs
organ rejection organ transplantation blood vessel
2021/8/10
Researchers have found a way to reduce organ rejection following a transplant by using a special polymer to coat blood vessels on the organ to be transplanted. The polymer substantially diminished rej...
Bio-inspired, blood-repelling tissue glue could seal wounds quickly
biocompatible glue stop bleeding operation
2021/8/10
Engineers have designed a strong, biocompatible glue that can seal injured tissues and stop bleeding, inspired by the sticky substance that barnacles use to cling to rocks.
Inspired by the sticky substance that barnacles use to cling to rocks, MIT engineers have designed a strong, biocompatible glue that can seal injured tissues and stop bleeding.
近日，中国科学院北京基因组研究所（国家生物信息中心）精准基因组医学重点实验室王前飞、李玥莹团队，首次绘制了小鼠巨核细胞的单细胞转录组图谱，揭示了体内巨核细胞在分子、空间分布及功能上的异质性。在此基础上提出了一种新的巨核细胞分类系统，而免疫巨核群体可能是一个新型造血分支。此项工作核心发现曾在2019年美国血液年会上荣获当年的最佳成果奖（BEST OF ASH）。研究成果以Single-Cell An...
复旦大学脑科学研究院赵冰樵课题组在Blood以封面论文发表最新研究成果（图）
脑出血 NETs cGAS
2021/7/30
2021年7月8日，复旦大学脑科学研究院、医学神经生物学国家重点实验室赵冰樵教授团队，以封面论文的形式，在《血液》（Blood）杂志上发表了题为“Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke（中性粒细胞NETs通过cGAS调控脑卒中后tPA溶栓出血）”...