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Implications of Ape1 in reactive oxygen signaling response following cisplatin treatment of dorsal root ganglion neurons
ROS APE1 base excision repair neurotoxicity
2014/12/12
Peripheral neuropathy is one of the major side-effects of the anticancer drug, cisplatin. Although previous work suggests that this neuropathy correlates with formation of DNA adducts in sensory neuro...
siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury
acute kidney injury siRNA
2014/12/11
Proximal tubule cells (PTCs), which are the primary site of kidney injury associated with ischemia or nephrotoxicity, are the site of oligonucleotide reabsorption within the kidney. We exploited this ...
A Phase II Study of Docetaxel,Cisplatin and 5- Fluorouracil (TPF) In Patients with Locally Advanced Head and Neck Carcinomas
Docetaxel Cisplatin 5-Fluorouracil Chemotherapy Head and neck Carcinoma
2015/9/22
Introduction: The combination of cisplatin and 5-fluorouracil (PF) is currently considered a standard and effective regimen for the treatment of advanced head and neck carcinomas. The aim of this stud...
Neoadjuvant Chemotherapy with Ifosfamide,Cisplatin,Adriamycin and Mitomycin (IMAP) for High risk Adult Soft Tissue Sarcomas
Soft tissue sarcoma neoadjuvant surgery chemotherapy
2009/12/16
To define efficacy of pre-operative chemotherapy in down staging of advanced non-round cell soft tissue sarcomas. From Sep 2002 to Dec 2005, 70 patients were treated by Ifosfamid, MESNA, cisplatin, ad...
Cisplatin Causes Oxidation in Rat Liver Tissues: Possible Protective Effects of Antioxidant Food Supplementation
Cisplatin hepatotoxicity antioxidant foods protection
2009/6/16
Aims: In this study, we aimed to investigate the possible molecular mechanism of cisplatin hepatotoxicity and to establish whether some natural antioxidant foods, namely dried black grape and tomato, ...
Celecoxib Enhances the Chemotherapeutic Response of Cisplatin and TNF-α in SiHa Cells through Reactive Oxygen Species-Mediated Mitochondrial Pathway
cervical cancer apoptosis celecoxib cisplatin TNF-α mitochondria
2009/4/20
Recently, many studies have shown that celecoxib induces apoptosis in various cancer cells by different mechanisms depending on the cell type. This study examined the effect of the selective COX-2 inh...
Metallothionein-IIA gene transcription in cisplatin-resistant cells and its metal-signalling mechanism by Cu(II) ion
Metallothionein-IIA gene transcription cisplatin-resistant cells metal-signalling mechanism
2009/4/1
Increased metallothionein (MT)-IIA transcription is found in some cells with acquired resistance to cisplatin (CDDP). It is also known that mammalian MT is induced by copper. MT induction by TPA (12-O...
Analysis of Cisplatin Behavior in a Non-Small Cell Lung Cancer（NSCLC）Cell Line
cisplatin resistance NSCLC intracellular Pt accumulation Pt-DNA adduct
2009/3/23
Cisplatin (CDDP) is an effective anticancer agent that is widely used in the treatment of testicular, ovarian, bladder and lung cancers. However the development of resistance to CDDP by tumor cells is...
Cisplatin-Induced Long-term Failure of Spermatogenesis in Adult C57/Bl/6J Mice
Apoptosis testis germ cell Sertoli cell
2008/12/23
Exposure to cisplatin results in impaired spermatogenesis, azoospermia, and, sometimes, permanent infertility in male patients. The mechanism(s) by which cisplatin induces damage to testicular cells...
顺铂温敏载药粒子的制备表征（Preparation and Characterization of Cisplatin-loaded Thermosensitive Micelle）
温敏 顺铂 靶向治疗
2010/8/18
制备了顺铂温敏载药纳米粒子，表征其相关性质并考察不同温度下对体外肿瘤细胞的生长抑制作用。制备的两亲嵌段聚合物在水溶液中自发形成胶束结构并包裹顺铂，测定顺铂载药粒子的结构、形态、粒径及包封率、载药量、晶体状态等特性，并对顺铂的体外释放以及不同细胞系体外毒性也做了研究。载药粒子粒径为83.3 ± 4.3 nm，载药量为37.8%，包封率为77.8%。血清中相变温度39.3 ℃。载药颗粒在单纯化疗时细胞...
PHASE II STUDY OF GEMCITABINE AND CISPLATIN IN ADVANCED NON-SMALL CELL LUNG CANCER
Non small cell lung cancer gemcitabine cisplatin
2010/2/4
Cisplatin-based chemotherapy is the standard treatment for advanced non-small cell lung cancer (NSCLC). Many novel drugs have been used in combination with cisplatin in this setting. Of these drugs, g...