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Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregates.
Super-resolution fluorescence huntingtin reveals growth globular species into short fibers coexistence distinct aggregates
2015/12/11
Polyglutamine-expanded huntingtin, the protein encoded by HTT mutations associated with Huntington's disease, forms aggregate species in vitro and in vivo. Elucidation of the mechanism of growth of fi...