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TFAM作为自噬受体介导胞质中mtDNA的清除进而限制炎症反应(图)
炎症 线粒体 蛋白复合物
2024/8/26
2024年5月23日,广州医科大学冯杜团队在Nature Cell Biology在线发表论文,报道了TFAM作为自噬受体介导胞质中mtDNA的清除,进而限制炎症反应
【目的】探讨甘肃截形叶螨Tetranychus truncatus种群遗传多样性、遗传分化及种群系统发育关系。【方法】本研究以2016年6-9月采自甘肃省8个不同生境的34个截形叶螨种群的518头螨样品进行mtDNA COI基因PCR扩增、测序,并利用MEGA7.0和Dna SP5.0等软件分析截形叶螨不同种群的mtDNA COI基因序列变异和遗传分化情况。【结果】在34个截形叶螨地理种群中共获得...
四川麻鸭mtDNA全序列的克隆和生物信息学分析
线粒体基因组 四川麻鸭 遗传进化
2017/4/1
本研究旨在获得四川麻鸭线粒体DNA基因组全序列(mtDNA),为该遗传资源的保护与利用提供参考。研究参照近缘物种线粒体基因组序列,用Primer 6.0设计引物16对,采用PCR克隆测序技术获得四川麻鸭mtDNA基因组序列。结果表明,四川麻鸭mtDNA基因组全长16 604 bp,碱基组成为A(29.19%)、C(32.82%)、G(15.79%)、T(22.20%),包含22个tRNA基因、2个...
mtDNA稀有变异或是精神分裂症一种病因
mtDNA稀有变异 精神分裂症
2016/8/4
近日,中国科学院昆明动物研究所研究员姚永刚、博士生毕蕊与中南大学湘雅二医院陈晓岗团队合作,对11个展现出母系遗传特征的精神分裂症家系进行了研究,通过测定各家系中先证者的mtDNA全基因组序列发现,mtDNA稀有致病变异可能是精神分裂症发病的一种病因,但其低频异质性很可能与精神分裂症不相关。相关结果近期分别发表于《精神分裂症的研究》 和《分子神经生物学》期刊。
Haplogroup Classification of Korean Cattle Breeds Based on Sequence Variations of mtDNA Control Region
Haplogroup mtDNA Control Region Korean Cattle Breed Phylogenetic Tree
2016/5/20
Many studies have reported the frequency and distribution of haplogroups among various cattle breeds for verification of their origins and genetic diversity. In this study, 318 complete sequences of t...
Genetic Diversity and Phylogenetic Analysis of South-East Asian Duck Populations Based on the mtDNA D-loop Sequences
Duck Populations D-loop Region Haplotype Mitochondrial DNA Phylogeny
2016/12/28
The maternally inherited mitochondrial DNA (mtDNA) D–loop region is widely used for exploring genetic relationships and for investigating the origin of various animal species. Currently, domestic duck...
Contrasting Population Structure from Nuclear Intron Sequences and mtDNA of Humpback Whales
Nuclear Intron Sequences mtDNA
2015/12/17
Powerful analyses of population structure require information from multiple genetic loci. To help develop a
molecular toolbox for obtaining this information, we have designed universal oligonucleoti...
Application of mtDNA markers for European huchen (Hucho hucho Linnaeus, 1758) management in Poland
Salmonidae broodstocks conservation genetic structure mtDNA
2015/12/17
Four broodstocks of European huchen (Hucho hucho) from Poland, Germany, Slovakia, and Ukraine were investigated using five selected fragments of mtDNA. The mitochondrial DNA sequence analysis was succ...
鸡mtDNA D-loop区单倍型簇频率与中国家鸡多母系起源研究
家鸡 mtDNA D-loop区 单倍型 聚类分析 频率 起源
2016/12/26
本研究旨在通过分析家鸡和原鸡D-loop区单倍型簇的区域性分布和频率揭示中国家鸡多母系起源的区域和传播途径。通过对1 347条鸡D-loop序列进行完全对比排序,共发现198种单倍型,聚成12个单倍型簇。分析结果显示,海岛型红色原鸡与家鸡和大陆型红色原鸡有明显差异;苏门答腊大陆型红色原鸡作为独立分支,也体现出与东南亚大陆型红色原鸡的区别。单倍型簇频率分析显示,Clade C代表的母系可能更早在东南...
为评价现有选育方式下的遗传结构现状及选育潜力,采用mtDNA D-loop序列差异分析技术,对埃及品系尼罗罗非鱼(Oreochromis niloticus)的3个选育世代群体共80尾鱼开展世代间遗传结构变异分析。结果显示:1)3个世代群体中个体序列长度为552~555 bp,包括52个变异位点、12个单倍型,平均单倍型多样度(H)为0.569;2)3个世代群体的核苷酸多态性(Pi)分别为0.02...
贵州东北部黑叶猴种群mtDNA D-loop序列多态性
黑叶猴 线粒体控制区 单倍型 遗传多样性
2016/7/18
贵州东北部作为黑叶猴在中国的主要分布区之一,黑叶猴的数量在近 30 年急剧下降,栖息地破碎化严重,保护形势不容乐观。深入了解黑叶猴在贵州东北部地区地理种群的分子变异及遗传水平现状,可以为黑叶猴保护提供重要的依据。本文以黑叶猴的粪便、毛发为实验材料,利用线粒体DNA分子标记,对采自贵州东北部地区黑叶猴野生种群79个粪便样品和黔灵公园笼养种群22个粪便样品、5份毛发样品的线粒体控制区(mtDNA D-...
We reexamined two mysterious beaked whale specimens stranded in Changle city of Fujian Province for species identification based on mtDNA sequences and morphological characters.By using DNA sequence s...
Enhanced mtDNA repair and cellular survival following oxidative stress by targeting the hOGG repair enzyme to mitochondria
DNA repair DNA damage
2014/12/12
Oxidative damage to mtDNA has been implicated as a causative factor in many disease processes and in aging. We have recently discovered that different cell types vary in their capacity to repair this ...
Effects of α-lipoic Acid on mtDNA Damage after Isolated Muscle Contractions
ISOLATED EXERCISE >-LIPOIC ACID PROPHYLAXIS MITOCHONDRIAL DNA DAMAGE LIPID PEROXIDATION
2017/7/17
ntroduction: Although pharmacological antioxidants have previously been investigated for a prophylactic effect against exercise oxidative stress, it is not known if α-lipoic acid supplementation can p...