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Peroxisomes as redox-signaling nodes in intracellular communication and stress responses
peroxisomes stress responses DNA repair systems CAT3 GSNOR
2023/12/6
Redox compartmentalization in organelles is an effective evolutionary strategy (Box 1; Jones and Go, 2010). From an evolutionary perspective, peroxisomes, originating from the endoplasmic reticulum (E...
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
西安交通大学生命学院一论文在Antioxidants & Redox Signaling上在线发表
西安交通大学生命学院 论文 Antioxidants & Redox Signaling 在线发表
2011/10/9
我校生命学院院长刘健康教授指导的研究团队和雀巢公司的研究人员经过大量的研究发现，在怀孕期间补充DHA能够有效提高胎儿大脑海马中线粒体的活性，消除产前应激所产生的不良影响，最终有效提高后代学习与记忆能力。近日，该项研究论文被自由基生物医学领域的权威期刊Antioxidants & Redox Signaling（影响因子8.2）在线发表。