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New Insights in the TSSK Family: Studies in the Activity and Function of the Testis Specific Serine Kinases
Capza3 Gamete Fusion Izumo Kinase Mouse sperm Tssk
2014/12/10
The Testis Specific Serine Kinase (Tssk) family of proteins is a large group of kinases that present high level of conservation within paralogs, as well as within species. In addition, in all reported...
An Integrative Approach Towards Understanding The Structure- Function Relationship Of The Epigenetic Regulator Methyl Cpg Binding Protein 2
Pure sciences Biological sciences Epigenetic regulator Methyl CpG Binding protein 2 Binding dynamics of caps Chromatin architectural proteins (caps) Intrinsically disordered protein Nucleosome Protein folding
2014/12/10
Methyl CpG binding protein 2 (MeCP2) is a methylated DNA binding protein which, when mutated, leads to a severe neurodevelopmental disorder known as Rett syndrome (RTT). In the present work I have sho...
Functional tests of structural models for abortive cycling in T7 RNA polymerase
Pure sciences Biological sciences Abortive cycling RNA polymerase Transcription
2014/12/10
Transcription initiates when the enzyme binds to the promoter region and melts open an initial transcribing bubble that extends from position -4 to +4. The initiation phase continues until the enzyme ...
Components of a Protein Machine: Allosteric Domain Assembly and a Disordered C-terminus Enable the Chaperone Functions of Hsp70
Allostery DnaK Hsp70 Intrinsic disorder Molecular chaperone Protein folding
2014/12/10
Hsp70 molecular chaperones protect proteins from aggregation, assist in their native structure formation, and regulate stress responses in the cell. A mechanistic understanding of Hsp70 function will ...
STRUCTURAL BIOLOGY AND PHARMACOLOGY OF HUMAN CATHEPSIN A AND NEURAMINIDASE 1
Cathepsin A Neuraminidase Lysosomal storage diseases sialidosis Galactosialidosis serine carboxypeptidase
2014/12/10
Human cathepsin A (also known as Protective Protein/Cathepsin A, PPCA; E.C. 3.4.16.5) is a lysosomal serine carboxypeptidase. Cathepsin A is also involved in a complex with two other lysosomal enzymes...
在组学水平高通量、系统地预测及筛选细粒棘球绦虫的分泌蛋白组，研究分泌蛋白及其信号肽特征，为后续诊断和疫苗相关抗原（簇）研究奠定基础。 方法 利用SignalP4.1 对细粒棘球绦虫全基因组蛋白序列进行信号肽预测，对含有信号肽的蛋白依次应用生物信息学软件TMHMM v2.0、Phobius、Big-PI predictor及TargetP1.1进行细粒棘球绦虫经典分泌蛋白质组筛选。随后利用LipoP...
α-突触核蛋白异常积聚的分子机理
α-突触核蛋白 积聚 分子机理 GAV模体
2013/9/27
α-突触核蛋白(α-Syn)的异常积聚与帕金森综合征的发生密切相关, 但是它的致病机理尚没有明确的定论. 本文介绍有关α-Syn异常积聚的分子机理研究的最新进展, 着重从积聚核心序列、抑制剂、结构转换和纤维形态4个方面加以讨论. 探索α-Syn积聚的分子机理对于了解这类疾病的致病原因, 开发新的预防和治疗手段具有重要意义
利用偶极子模型研究肌球蛋白Ⅵ的定向运动
分子马达 肌球蛋白Ⅵ 朗之万方程 电偶极子
2013/9/17
从整个肌球蛋白分子马达系统的结构特点和实验现象出发, 利用电偶极子模型构建一个势能函数, 应用朗之万方程讨论其定向运动行为. 通过调整分子马达电偶极子参数, 模拟得到了肌球蛋白Ⅵ分子马达系综沿微丝负向的平均位移和平均粒子流, 并讨论了负载力和马达偶极子转动速率对肌球蛋白Ⅵ系综运动的影响. 研究发现, 分子马达的运动方向会随马达偶极子旋转方向的不同而变化, 马达偶极子逆时针旋转时分子马达向微丝负端运...
ANALYSIS OF THE INTERACTION BETWEEN TOMATO TORRADO VIRUS PROTEINS USING THE YEAST TWO-HYBRID SYSTEM
gateway strategy Tomato torrado virus viral proteins interaction yeast two-hybrid system
2014/2/21
Ten years ago for the first time the new picorna-like virus species – Tomato torrado virus (ToTV) – was found and described
on tomato plants. The isolates of this pathogen were reported in Europe, A...
核糖核酸酶(Ribonucleases, RNase, RNS)T2普遍存在于各种生物中,其保守性提示了功能的重要性。在水稻基因组中有8个RNase T2成员,本试验采用基于抗体的蛋白质组学策略,用免疫印迹(Western Blotting,WB)技术检测了它们在叶片生长及盐胁迫条件下的表达,发现OsRNS1-OsRNS7蛋白质在叶片中有表达,其中OsRNS4主要在苗期表达,提示其在苗期发挥作用,...
Regulation of outer surface lipoprotein A in the Lyme disease spirochete Borrelia burgdorferi
Borrelia burgdorferi OspA
2015/5/21
Borrelia burgdorferi, a bacterium which causes Lyme disease, is maintained in nature through a cycle involving two distinct hosts: a tick vector and a mammalian host. To adapt to these two diverse env...
张世华与其合作者在2010年发表在生物信息学领域的旗舰杂志Bioinformatics的题为“A fast mathematical programming procedure for simultaneous fitting of assembly components into cryo-EM density maps”的论文，系统地引进了将多个蛋白质三维结构元件一起装配到大分子复合物的低温电...
解淀粉芽孢杆菌对鱼腥藻的抑藻效果分析与机理初探
解淀粉芽孢杆菌 抑藻效果 水华鱼腥藻 溶藻机理
2011/7/27
解淀粉芽孢杆菌(Bacillus amyloliquefaciens)在自然界广泛分布,可通过分泌抗生素、抗菌蛋白或多肽类物质起到生物防治作用,但在抑藻方面的研究还处于空白状态.本研究从滇池富营养化水体中分离得到一株溶藻细菌DC1,对该菌的抑藻效果和溶藻机理进行了研究,并通过16S rRNA 序列分析方法对其进行种属鉴定.结果表明,溶藻菌株DC1为解淀粉芽孢杆菌,对水华鱼腥藻具有高效抑藻效果,当初...
蚊嗅觉结合蛋白和嗅觉受体的研究进展
蚊 嗅觉 嗅觉结合蛋白 嗅觉受体
2013/11/27
蚊的许多行为很大程度上都依赖于嗅觉，嗅觉对其生存与繁殖起着重要作用。蚊的嗅觉系统，主要包括嗅觉结合蛋白、嗅觉受体以及相关的神经元。该文主要对蚊嗅觉结合蛋白和嗅觉受体的研究进展进行综述。