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Dynamics of Protein Relaxation in Site-Specific Mutants of Human Myoglobin
Humans Cysteine Heme Alanine Myoglobin Recombinant Proteins Spectrophotometry Mutagenesis,Site-Directed Amino Acid Sequence Protein Conformation
2016/5/23
We have recently reported spectroscopic evidence for structural relaxation of myoglobin (Mb) following photodissociation of MbCO [Lambright, D. G., Balasubramanian, S., & Boxer, S. G. (1991) Chem. Phy...
Perturbations of the Distal Heme Pocket in Human Myoglobin Mutants Probed by Infrared Spectroscopy of Bound CO:Correlation with Ligand Binding Kinetics
Distal Heme Pocket Human Myoglobin Mutants Probed Infrared Spectroscopy Bound CO:Correlation Ligand Binding Kinetics
2016/5/23
The infrared spectra of CO bound to human myoglobin and myoglobin mutants at positions His-64, Val-68, Asp-60, and Lys-45 on the distal side have been measured between 100 and 300 K. Large differences...
Spectroscopic and Redox Properties of Sym1 and (M)F195H Rhodobacter capsulatus Reaction Center Symmetry Mutants Which Affect the Initial Electron Donor
Circular Dichroism Electron Spin Resonance Spectroscopy Electron Transport Genes, Bacterial Kinetics Light-Harvesting Protein Complexes Mutation Oxidation-Reduction Photosynthetic Reaction Center Complex Proteins Plasmids Protein Conformation Rhodobacter capsulatus Spectrophotometry
2016/5/23
The redox properties, absorption, electroabsorption, CD, EPR, and P+QA- recombination kinetics have been measured for the special pairs of two mutants of Rhodobacter capsulatus reaction centers involv...
Selective Examination of Heme Protein Azide Ligand-Distal Globin Interactions Vibrational Circular Dichroism
Heme Protein Azide Ligand-Distal Globin Vibrational Circular Dichroism
2016/5/23
Vibrational circular dichroism (VCD) spectra of the antisymmetric stretch of azide ligated to the heme of a series of evolutionarily diverse and site-direct mutant hemoglobins and myoglobins are anoma...
Electric Field Effects on Kinetics of Electron Transfer Reactions:Connection Between Experiment and Theory
ADSORPTION KINETICS PROTEINS STRUCTURAL STABILITY
2016/5/23
The dependence of the rate constant for electron transfer on energy can be systematically studied by measuring kinetics in an applied electric field. General relationships are developed between observ...
Dielectric Relaxation in a Protein Matrix
biology and medicine, basic studies chemistry proteins solvation dielectric properties time dependence relaxation fluorescence
2016/5/23
We report measurements of time-dependent solvation in a protein medium by the fluorescence dynamic Stokes shift method. Picosecond time-correlated single photon counting fluorescence decays on the com...
Stark Effect Spectroscopy of Bacteriochlorophyll in Light-harvesting Complexes from Photosynthetic Bacteria
Stark effect Electric field effect Antenna complex Light harvesting complex Energy transfer BCP bacteriochlorophyll a protein RC reaction center
2016/5/23
The effects of an applied electric field on the Q y absorption and fluorescence spectra of three antenna complexes from photosynthetic bacteria have been measured at 77 K: the bacteriochlorophyll a pr...
X-ray Crystal Structure of a Mutant Recombinant Human Myoglobin at 2.8Å Resolution
Humans Myoglobin Recombinant Proteins X-Ray Diffraction Protein Conformation Mutation Molecular Structure
2016/5/23
We have grown crystals in trigonal space group P 3 2 21 of a mutant human myoglobin, aquomet form, in which lysine at position 45 has been replaced by arginine and cysteine at position 110 has been re...
Stark Effect Spectroscopy of the Rhodobacter sphaeroides Reaction Center Heterodimer Mutant
Rhodobacter sphaeroides Macromolecular Substances Light-Harvesting Protein Complexes Photosynthetic Reaction Center Complex Proteins Bacterial Proteins Spectrophotometry Mutation Thermodynamics
2016/5/23
The effect of an electric field has been measured on the absorption spectrum (Stark effect) of the heterodimer mutant (M)H202L of Rhodobacter sphaeroides reaction centers, where the primary electron d...
干预载脂蛋白AⅠ表达的研究进展
高密度脂蛋白 载脂蛋白AⅠ 心血管疾病
2018/9/20
大量的临床流行病学研究已经表明,高密度脂蛋白(HDL)水平与心血管疾病风险呈负相关。载脂蛋白AⅠ(ApoAⅠ)是HDL中的主要功能蛋白,其含量约占HDL的70%左右。寡脂的ApoAⅠ是ATP结合盒转运子A1 (ABCA1)介导的巨噬细胞胆固醇流出的主要接受体,能够介导巨噬细胞中游离胆固醇的外流,启动胆固醇逆转运(RCT)过程,并在肝外组织清除过多胆固醇。大量的动物实验也已证实即使HDL保持正常水平...
Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression
ERG protein expression TMPRSS2:ERG lycopene prostate cancer tomato sauce
2018/11/28
Background: There is limited evidence that supports etiologically distinct molecular subtypes of prostate cancer, the identification of which may improve prevention. Given their antioxidant properties...
Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial
athlete dietary protein leucine skeletal muscle resistance exercise high-intensity interval training
2018/11/28
Background: A dietary protein intake higher than the Recommended Dietary Allowance during an energy deficit helps to preserve lean body mass (LBM), particularly when combined with exercise.
High protein intake in young children and increased weight gain and obesity risk
High protein intake young children increased weight gain
2018/11/27
An adequate supply of protein and essential amino acids is of fundamental importance for normal child growth and development. Because pediatric nutrition research evolved from treating and preventing ...
Acute effect of red meat and dairy on glucose and insulin: a randomized crossover study
dairy dietary proteins insulin sensitivity red meat glucose metabolism
2018/11/23
Background: In contrast with some epidemiologic evidence, our previous research showed that a 4-wk diet that was high in low-fat dairy reduced insulin sensitivity compared with the effect of a diet th...
In response to glucose, pancreatic islet beta cells secrete insulin in a biphasic manner, and both phases are diminished in type 2 diabetes. In beta cells, cortical F-actin beneath the plasma membrane...