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43岁的老何从去年开始总觉得胸闷，一干活儿就喘粗气，前后跑了多家三甲医院，抽了80多管血，排查了肺炎，又抗结核治疗了一段时间，打了引流管，做了气管镜、穿刺，治疗却毫无进展。老何的情况越来越糟，左右两个肺里全是积水，不是肺癌、肺炎，也排除了肺结核，却还是查不出病因。
实验室肺结核病学组发现增强而非抑制谷氨酸激酶可以杀死结核分枝杆菌（图）
谷氨酸激 呼吸健康研究院 结核分枝杆菌 TB药物
2023/4/12
近日，实验室肺结核病学组张天宇教授研究团队、刘健雄教授研究团队联合深圳市第三人人民医院（黄乃淇）及奥尔巴诺瓦大学中心KTH皇家理工学院（周洋）等单位合作发现谷氨酸激酶（glutamate kinase, GK）可能成为抗TB药物的新靶标。本研究首次报道了小分子增强而不是抑制代谢酶的活性可成为潜在抗结核药物的新策略。相关研究成果以“Quinoline derivatives kill Mycobac...
Comparative Study Of HIV Associated Pulmonary Tuberculosis In Chest Clinics From Two Regions Of Edo State,Nigeria
HIV Pulmonary Tuberculosis Edo State
2015/7/30
A comparative study of HIV associated pulmonary tuberculosis (HIV-PTB) was carried out in Chest Clinics situated in Benin and Irrua environs of Edo State, Nigeria, using microscopical and serological ...
Circumstances and consequences of falls among people with chronic stroke
chronic stroke mobility falls injury rehabilitation
2014/11/26
Falls are common after stroke; however, circumstances and consequences are relatively unknown. Our objectives were to identify the differences between fallers and non-fallers among people with chronic...
肝内胆管细胞癌（ICC）发生于二级胆管以上的末梢侧肝内小胆管，起自肝内胆管上皮细胞。ICC生物学特性复杂，误诊率高，诊断主要依据影像学手段。正电子发射计算机体层显像（PET-CT）是将PET设备和CT设备融为一体的同时具备形态学和功能学诊断的尖端影像设备。肿瘤诊断已成为PET-CT临床应用的主要内容。因此详细研究PET-CT在ICC诊断中的应用价值，将会提高ICC的诊断率。现将PET-CT在ICC...
探讨共干扰质粒pGenesil-2.1-PTTG-survivin siRNA对U251细胞人垂体瘤转化基因（PTTG）和生存素（survivin）基因表达的影响。方法：U251细胞分为5组，分别为正常细胞对照组、Lipo2000+ 〖JP〗pGenesil-2.1 HK组(HK阴性对照组)、Lipo2000+pGenesil-2.1-PTTG siRNA、Lipo2000+ pGenesil-2...
泛耐药结核病研究现状和诊治对策
耐药结核病 研究现状 诊治对策 抗结核药
2011/4/1
每年，全世界有超过900万人感染结核。正如WHO报道的，难治的耐药结核菌株在不多增多，而耐多药结核（MDR-TB）——定义为至少对两种最有效的抗结核药物即利福平和异烟肼耐药的结核菌株——每年的新发病例约有50万例。更为可怕的是临床已经发现全耐药结核菌，即对所有已知的抗结核药物都耐药。如何找到耐药结核发病原因，并积极地、有效地、迅速地进行治疗，杜绝滋生MDR和XDR结核菌的环境，是当前迫在眉睫的问题...
6例肠结核术后合并肠外瘘救治
肠结核 合并 肠外瘘 救治
2011/9/2
总结肠结核因伴有外科并发症时，需经手术治疗后合并肠外瘘救治的临床经验。方法 回顾性分析2000 ~2008年在我院普通外科收治的出现了急性穿孔、完全性肠梗阻、腹部包块未能排除恶性肿瘤的6例肠结核患者，手术切除主要病变肠段I期吻合术后合并肠外瘘诊治过程。结果 本组中5例患者4周至6月瘘口自然闭合。1例患者因肠外瘘合并感染1周内死亡。结论 肠结核应以内科治疗为主，因伴有外科并发症而手术治疗后合并肠外瘘...
A Patient with Bronchial Asthma in Whom Eosinophilic Bronchitis and Bronchiolitis Developed during Treatment
bronchial asthma bronchiolitis eosinophilic bronchiolitis eosinophilic lung disease
2010/11/12
A 56-year-old woman was referred to our hospital because of dyspnea, wheezing, and a productive cough. Eight years before presentation, bronchial asthma was diagnosed and the patient received inhaled ...
Multifocal skeletal Tuberculosis:Bone scan appearance
Multifocal skeletal Tuberculosis Bone scan appearance
2010/1/6
Multifocal skeletal tuberculosis in not uncommon in the countries with tuberculosis. The clinical onest is insidious and sometimes nonspecific, resulting in delay or misdiagnosis. Bone scan appearance...
Efficiency of PCR Method for Screening Pulmonary Tuberculosis Patients under DOTs Protocol Therapy
Tuberculosis disease Screening method
2009/12/29
Tuberculose has increased in the recent years. Use of a sensitive screening method, can be one of the influential parameters in reduction of pulmonary tuberculosis. Current screening method in the lab...
Tuberculosis is an important opportunistic disease among HIV- infected persons worldwide; from March 1999 to Feburery 2001 we had seventeen patients with HIV-infection and tuberculosis. Here we are pr...
Splenic Tuberculosis is a rare entity, particularly among immunocompetent hosts. Hererin, we present a 23 year-old man who was reffered with fever of unknown origin and eventually diagnosed to have sp...
Pelvic Peritoneal Tuberculosis Mimicking Stage IV Ovarian Cancer:Case Report
CA125 Tuberculosis Ovarian cancer
2009/12/15
Tuberculosis (TB) is the most common infectious cause of human death. After the lung, genitourinary tract is the most common site for TB infection. Pelvic tuberculosis should be considered in young wo...
Quality Control of Sputum Smears Examination by Re-Reading in a Tuberculosis Screening
Double-reading Tuberculosis screening Quality control
2009/12/15
Background: Sputum smear examination is the basis of diagnosis of tuberculosis and quality control for the correct diagnosis of tuberculosis is necessary. This study was a method survey and perfo...