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The prevalence of asthma has been increasing in Japan, like in other parts of the world. Asthma management guidelines were developed in Japan in 1993 and 1998. These guidelines have been shown to cont...
Questionnaire-based characterization of bronchial asthma in the elderly: Analysis in Niigata Prefecture, Japan
bronchial asthma education elderly guidelines questionnaire
2010/11/24
Based on sufficient consideration of the problems specifically related to elderly asthmatic patients, adequate education and careful management of asthma in this group are required, and the accumulati...
Perioperative corticosteroids for intermittent and mild persistent asthma
airway hyperresponsiveness bronchial asthma general anesthesia perioperative bronchospasm
2010/11/24
Only three cases (4.0%) developed mild asthma during the perioperative period. No evidence of adverse effects of corticosteroids was noted in any case. The use of the same therapeutic regimen in anoth...
Current and potential improvements in the treatment of asthma from increased understanding of airway pathophysiology
β-adrenergic receptor agonists anti-IgE antibody anti-interleukin-5 monoclonal antibody asthma corticosteroids leukotriene inhibitors theophylline
2010/11/24
The mainstay of chronic asthma management consists of using pharmacological agents that induce broncho-dilatation, such as short-acting β-adrenergic receptor agonists (bronchodilators or relievers), a...
Risk factors for asthma and allergic diseases among 13-14-year-old schoolchildren in Japan
allergy asthma childhood International Study of Asthma and Allergies in Childhood prevalence risk factor
2010/11/24
In analyses of family histories, the odds ratios (OR) of children who have a family history with no symptoms were significantly lower by risk factor-based analyses compared with those children with a ...
Anti-endothelial cell IgE antibodies in children with bronchial asthma
anti-endothelial cell antibodies bronchial asthma IgE
2010/11/24
In the cellular ELISA, the IgE class of AECA was detected significantly more frequently in children with asthma (25/156; 16.0%) than in healthy controls (2/203; 1.0%; P > 0.01). There were no differen...
A Study of 456 cases of death from asthma (1993-1997) from an investigation by the Tokyo Medical Examiner's Office
asthma death bronchial asthma living alone metered dose inhaler risk factor
2010/11/24
Those living alone have a significantly lower likelihood of receiving emergency medical care immediately before death compared with those living with other people. The cases of acute death within 3 h ...
Effect of short-course steroid treatment for airway inflammation in patients with asthma
asthma bronchial biopsy corticosteroid eosinophil lymphocyte
2010/11/24
Background: The effect of short-term corticosteroid treatment for airway inflammation in asthma is not well known. To investigate this effect, we analyzed bronchial mucosal biopsy samples.
Methods: W...
Early treatment in asthma: How early is early?
early asthma eosinophilic inflammation inhaled corticosteroids
2010/11/24
In the 1990s, the definition of asthma changed as we realized that asthma is fundamentally an inflammatory disorder. It was also shown in both adults and children that treatment should be initiated wi...
Immunomodulation in the treatment and/or prevention of bronchial asthma
bacillus Calmette-Guérin vaccine bronchial asthma cytosine guanosine oligonucleotide eosinophils IgE/anti-IgE immunotherapy Th1/Th2 cytokines
2010/11/24
The immunologic hallmark of atopic allergy and asthma is an increased production of IgE and T helper (h) type 2 cell cytokines (interleukin (IL)-4, IL-5, IL-9 and IL-13) by Th cells reacting to common...
Exhaled nitric oxide as a marker of atopic asthma
asthma atopy children cromone exhaled nitric oxide inhaled steroid skin prick test
2010/11/24
Background: The aim of the present study was to assess the effect of atopy and regular therapy for asthma on exhaled nitric oxide (eNO).
Methods: Exhaled NO was measured using a chemiluminescence ana...
Inverse association between daily activity and sleep activity and related factors in elderly patients with chronic obstructive pulmonary disease and bronchial asthma
bronchial asthma chronic obstructive pulmonary disease daily activities elderly patients sleep quality
2010/11/24
It is assumed that elderly subjects with COPD or bronchial asthma require a longer sleep period than subjects without respiratory symptoms because of the deterioration of sleep quality in the former g...
Attenuation of allergic airway inflammation and associated pulmonary functions by mycobacterial antigens is independent of IgE in a mouse model of asthma
airway hyperresponsiveness asthma Bacillus Calmette-Guérin eosinophils IgE Mycobacterium vaccae
2010/11/24
Neither BCG nor M. vaccae were able to attenuate the EAR, yet both were able to abrogate the parameters used to evaluate the LAR. Interestingly, in neither case were serum or OVA-specific IgE levels r...
Population pharmacokinetics of pranlukast hydrate dry syrup in children with bronchial asthma
children with bronchial asthma population pharmacokinetics pranlukast
2010/11/24
Apparent clearance (CL/F) was 1.81 and 1.14 L/h per kg in children and adults, respectively. According to subgrouping of children, no significant difference was observed in CL/F between infants (3-6 y...
Clinical and experimental studies on fibronectin in bronchial asthma
bronchial asthma eosinophil adherence eosinophil chemotaxis eosinophils fibronectin
2010/11/24
Background: Clinical and experimental studies were performed to investigate the kinetics of fibronectin (FN) and its clinical significance in bronchial asthma.
Methods: Measurements of plasma fibrone...