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IMPACT OF ALCAM (CD166) ON HOMING OF HEMATOPOIETIC STEM AND PROGENITOR CELLS
endosteal bone marrow vascular bone marrow flow cytometry
2015/5/25
The potential of hematopoietic stem cells (HSC) to home and to anchor within the bone marrow (BM) microenvironment controls the ability of transplanted HSCs to establish normal hematopoiesis. Activate...
Shp2 deletion in post-migratory neural crest cells results in impaired cardiac sympathetic innervation
Shp2 pERK Bradycardia
2015/5/25
Autonomic innervation of the heart begins in utero and continues during the neonatal phase of life. A balance between the sympathetic and parasympathetic arms of the autonomic nervous system is requir...
Tsg-6 : an inducible mediator of paracrine anti-inflammatory and myeloprotective effects of adipose stem cells
Adipose stem cell inflammation TSG-6 hematopoiesis smoking
2015/5/22
Tumor necrosis factor-induced protein 6 (TSG-6) has been shown to mitigate inflammation. Its presence in the secretome of adipose stem / stromal cells (ASC) and its role in activities of ASC have been...
Reconstitution of mouse inner ear sensory development from pluripotent stem cells
Inner ear Pluripotent stem cells Hair cells
2015/5/21
The inner ear contains specialized sensory epithelia that detect head movements, gravity and sound. Hearing loss and imbalance are primarily caused by degeneration of the mechanosensitive hair cells i...
An inhibitor of the mitotic kinase, MPS1, is selective towards pancreatic cancer cells
CIN70 MPS1 kinase inhibitor pancreatic cancer
2015/5/21
The abysmal five year pancreatic cancer survival rate of less than 6% highlights the need for new treatments for this deadly malignancy. Cytotoxic drugs normally target rapidly dividing cancer cells b...
Molecular switch matures heart cells derived from stem cells（图）
Molecular switch matures heart cells derived stem cells
2015/5/25
A molecular switch that seems to be essential for embryonic heart cells to grow into more mature, adult-like heart cells has been discovered. The discovery should help scientist better unde...
Warming-Up Affects Performance and Lactate Distribution between Plasma and Red Blood Cells
Lactate concentration blood performance enhancement anaerobic exercise cycling competition preparation
2015/5/5
Warming-up (WU) is a widely used preparation for training and competition. However, little is known about the potential mechanisms of WU on performance and on the lactate distribution in the blood com...
Mesenchymal Stem Cells Augment the Adaptive Response to Eccentric Exercise
A7 INTEGRIN SATELLITE CELLS STEM CELL ANTIGEN-1 DOWNHILL RUNNING REPAIR GROWTH
2017/4/14
Purpose: The α7β1 integrin is a transmembrane protein expressed in the skeletal muscle that can link the actin cytoskeleton to the surrounding basal lamina. We have previously demonstrated that transg...
Metastatic breast cancer and circulating tumour cells
Metastatic breast cancer circulating tumour cells
2015/4/14
Circulating tumour cells – often referred to as a ‘liquid biopsy’ for cancer – can be found in a large proportion of patients with breast cancer that has spread to other organs. Changes in circulating...
Disparate functions of myeloid-derived suppressor cells in cancer metastasis
Disparate functions cancer metastasis
2015/4/14
Myeloid-derived suppressor cells comprise a heterogeneous population of immature immune cells that expand during the course of cancer progression. These cells adopt an immunosuppressive phenotype that...
There are few times in life when one should aim for suboptimal performance, but new research at Rice University suggests scientists who study metabolism and its role in evolution should look for signs...
Sound separates cancer cells from blood samples
Sound separates cancer cells blood samples
2015/4/13
Separating circulating cancer cells from blood cells for diagnostic, prognostic and treatment purposes may become much easier using an acoustic separation method and an inexpensive, disposable chip, a...
UCSF Team Finds Key to Making Neurons From Stem Cells（图）
UCSF Team Making Neurons Stem Cells
2015/3/25
A research team at UC San Francisco has discovered an RNA molecule called Pnky that can be manipulated to increase the production of neurons from neural stem cells.The research, led by neurosurgeon...
Effects of Collagen Gel Stiffness on Cdc42 Activities of Endothelial Colony Forming Cells during Early Vacuole Formation
ECFC Vacuole Cdc42 Stiffness FRET
2015/1/12
Recent preclinical reports have provided evidence that endothelial colony forming cells (ECFCs), a subset of endothelial progenitor cells, significantly improve vessel formation, largely due to their ...
Adipose stromal cells enhance keratinocyte survival and migration in vitro, and graft revascularization in mouse wound healing model
ASC adipose stromal cell wound healing Integra burn adipose stem cell keratinocyte endothelial cell
2015/1/12
In the US, more than 1 million burn injuries are reported annually. About 45,000 injuries due to fires and burns result in hospitalization and ten percent of these result in death every year. Advances...