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Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
Synthesis and Mechanistic Studies of a Novel Homoisoflavanone Inhibitor of Endothelial Cell Growth
Endothelial Cell Growth Synthesis and Mechanistic
2014/11/25
Preventing pathological ocular angiogenesis is key to treating retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. At present there is no small molecule drug on the ...
Multimodality Imaging Methods for Assessing Retinoblastoma Orthotopic Xenograft Growth and Development
Retinal cell tumor Growth and Development
2014/11/25
Genomic studies of the pediatric ocular tumor retinoblastoma are paving the way for development of targeted therapies. Robust model systems such as orthotopic xenografts are necessary for testing such...
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
autocrine signaling bone marrow cells breast cancer
2014/11/6
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB...
The Effects of Insulin-Like Growth Factor-1 Gene Therapy and Cell Transplantation on Rat Acute Wound Model
IGF-1 Gene Therapy Cell Transplantation Fibroblast Wound Healing
2015/10/15
Background: Wound healing is a complex process. Different types of skin cells, extracellular matrix and variety of growth factors are involved in wound healing. The use of recombinant growth factors i...
Growth Disorders Among 6-Year-Old Iranian Children
Body Mass Index Child Socioeconomic Factors
2015/10/13
Background:: Sociodemographic factors are important determinants of weight disorders. National representative studies provide a view on this health problem at national and regional levels.
A Multicenter Study on Expressions of Vascular Endothelial Growth Factor, Matrix Metallopeptidase-9 and Tissue Inhibitor of Metalloproteinase-2 in Oral and Maxillofacial Squamous Cell Carcinoma
Oral Surgical Procedures Carcinoma Squamous Cell
2015/10/12
Background:: Vascular endothelial growth factor (VEGF), matrix metallopeptidase-9 (MMP-9) and tissue inhibitor of metalloproteinase-2 (TIMP-2) are potential markers of oral and maxillofacial squamous ...
Scientists from USC and NYU design a molecule that blocks cancer growth in mice
Scientists from USC NYU design a molecule blocks cancer growth in mice
2014/6/12
A team of researchers from USC and NYU has developed and patented a small molecule that interferes with cancer progression with minimal side effects.
The molecule prevents two critical proteins from ...
Musculoskeletal and Estrogen Changes during the Adolescent Growth Spurt in Girls
PUBERTY INJURIES LOWER LIMB, ACL
2017/7/14
Introduction: The adolescent growth spurt is associated with rapid growth and hormonal changes, thought to contribute to the increased anterior cruciate ligament injury risk in girls. However, relativ...
Brain Nerve Growth Factor Unbalance Induced by Anabolic Androgenic Steroids in Rats
NERVE GROWTH FACTOR ANABOLIC ANDROGENIC STEROIDS HIPPOCAMPUS BASAL FOREBRAIN NEUROTROPHIC UNBALANCE, NGF RECEPTORS
2017/7/14
Purpose: Anabolic androgenic steroids (AAS) are synthetic androgen-like compounds that are abused in sport communities despite their adverse effects. Nerve growth factor (NGF) influences neuronal diff...
High Volumes of Resistance Exercise Are Not Required for Greater Bone Mineral Density during Growth
TIBIA, FEMUR DXA THREE-POINT BENDING TEST
2017/7/14
Purpose: The purpose of this study was to determine the minimum amount of resistance exercise that would stimulate bone formation, via an elevation in bone mineral density (BMD), during the growth per...
Vernonia amygdalina—Induced Growth Arrest and Apoptosis of Breast Cancer (MCF-7) Cells
Vernonia amygdalina MCF-7 Cells Apoptosis Necrosis Cellometer Imaging
2013/2/19
Breast cancer is the second leading cause of cancer-related deaths of women in the United States. Fortunately, the mortality rate from breast cancer has decreased in recent years due to an increased e...
Growth Performance of Broiler Chickens Fed Fossil Shell Growth Promoter
Fossil Shell Performance Calcium Phosphorus Broilers
2013/1/29
A study was carried out to determine the influence of fossil shell (diatomaceous earth) supplemented diets on the performance and bone composition of broiler chickens. A total of 120 day old broiler c...
Semi-Automated Method for Multi-Tasking Measurement of Microbial Growth, Capsule, and Biofilm Formation
Biofilm Staphylococcus aureus Escherichia coli Quorum-Signaling Compounds
2013/1/29
The majority of bacterial infections involve the formation of biofilms. Biofilm formation is nutrient and growth dependent. Determination of the effects of nutrients on exopolysaccharide production an...
Growth and differentiation factor-11 is developmentally regulated in skeletal muscle and inhibits myoblast differentiation
GDF-11 Developmental Expression Post-Natal Muscle Growth Sexual Dimorphism Myoblast Differentiation
2013/1/30
Growth and differentiation factor-11 (GDF-11) is a secreted protein that is closely related to myostatin, a known inhibitor of skeletal muscle development. The role of GDF-11 in regulating skeletal mu...