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The cytomorphological analysis of buccal mucosa cells in smokers
Oral exfoliative cytology cytomorphometry smoking buccal mucosa
2011/3/22
To examine the effect of smoking on normal buccal mucosa cytomorphologically. Materials and methods: Forty individuals aged between 40 and 60, comprising 23 smokers (14 male, 9 female) and 17 and non-...
In vitro effect of resveratrol against oxidative injury of human coronary artery endothelial cells
Resveratro human coronary artery endothelial cell oxidative stress
2011/3/22
Reactive oxygen species induce oxidative stress that may contribute to endothelial dysfunction. In addition to endogen antioxidants, adding antioxidants to diet has been used to reduce oxidative-stres...
Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice
Rapamycin tacrolimus rejection
2013/6/26
Donor-reactive memory T (Tm) cells undermine transplanted organs more readily than naive T cells. Rapamycin (RAPA) and tacrolimus (FK-506) are current mainstay immunosuppressants used for preventing a...
The development of a tissue-engineered artery using decellularized scaffold and autologous ovine mesenchymal stem cells
artery stem
2013/6/26
Alternatives to using native arteries in vascular surgery are urgently needed. Vessels made from synthetic polymers have shortcomings such as thrombosis, rejection, intimal hyperplasia, calcification,...
Curdlan Induces DC-Mediated Th17 Polarization via Jagged1 Activation in Human Dendritic Cells
adjuvant dendritic cells Notch ligand Th17 β-gulcan
2010/11/12
Background: Th17-inducing activity is carried by certain polysaccharides such as β-glucan derived from Candia albicans. Our previous studies have shown that Th1- and Th2-inducing activities can be qua...
Importance of IL-18-Induced Super Th1 Cells for the Development of Allergic Inflammation
allergic inflammation atopic dermatitis bronchial asthma IL-18 super Th1
2010/11/12
Th1 cells, which express IL-18R, produce IFN-γ in response to Ag and IL-2 and increase further production of IFN-γ upon additional IL-18 stimulation. They simultaneously produce Th2 cytokines (IL-9 an...
Alarming Dendritic Cells for Allergic Sensitization
alarmins asthma danger signals dendritic cells IL-1
2010/11/12
Allergic patients mount a Th2 response to common allergens, like house dust mite (HDM), pollens, molds and animal dander. Most inhaled antigens are immunologically inert, however if these antigens are...
Breast cancer stemlike cells and breast cancer therapy
Breast cancer stem cells Signaling pathway Resistance
2012/7/13
Until the early 1990s, human cancers were considered a morphologically heterogeneous population of cells. In 1997, Bonnet et al demonstrated that a small population of leukemia cells was able to diffe...
Effect of chondroitin sulfate-E on the osteoclastic differentiation of RAW264 cells
Chondroitin sulfate Osteoclast Calcium phosphate
2010/11/29
The present study was designed to investigate whether chondroitin sulfate (CS)-E, a CS structural isomer variant, alter the differentiation of macrophage cell line RAW264 cells to osteoclast-like cell...
New study investigates infection of human cells in space
New study infection of human cells space
2010/4/29
In a first-of-its-kind experiment, the unique conditions of space flight will be used to examine how cells remain healthy or succumb to disease, particularly in the face of stress or damage.
Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials
Restorative materials Resins Mesenchymal cells
2010/11/29
This study investigated the proliferation and differentiation potential of pluripotent mesenchymal cells on three resin-based restoratives using a typical pluripotent mesenchymal precursor cell line, ...
Bone stem cells could in future be used as part of an innovative new hip replacement treatment, rather than using bone from deceased donors, according to a new research proposal funded by the Medical ...
Naringenin Chalcone Suppresses Allergic Asthma by Inhibiting the Type-2 Function of CD4 T Cells
airway hyperreactivity asthma prevention Th2 cell tomato extract
2010/11/12
Background: Some polyphenols possess anti-allergic activities. Naringenin chalcone is one of the polyphenols that is present in the skin of red tomatoes. In this study, we investigated the effect of n...
Discovery of new immune cells offers hope of asthma treatment
new immune cells asthma treatment
2010/3/10
Researchers at the Medical Research Council (MRC) have discovered a new type of immune cell which could eventually lead to new preventative treatments for asthma.These newly-discovered cells, called ‘...
Understanding of the particular cancer cells within a tumour that drive its growth could now advance more rapidly, thanks to Oxford University scientists.
They show in the journal PNAS how a crucial...