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An apparatus which enables aggregating agents to be added to a stirred suspension of platelets subjected to a pressure of up to 600 ATA is described. The ensuing aggregation reaction is monitored opti...
Effect of barbituric acid on the high pressure nervous syndrome in the rat
neurological rat animal high pressure nervous syndrome barbituric acid
2009/7/14
Male Sprague-Dawley rats were compressed in helium-oxygen mixture at a rate of 3 bar/min. Compression ended once the first convulsion was seen. Saline or barbituric acid at 1 or 2percent were infused ...
Effect of 2-aminophosphonoheptanoic acid on the EEG of rats exposed to high pressure
neurological rat animal
2009/7/14
Excitatory amino acid neurotransmission may be involved in the tremor component of the high pressure neurological syndrome (HPNS). 2-Amino-7-phosphonoheptanoic acid (2-APH) is a novel antagonist of ex...
Free radical reactions and the inhibitory and lethal actions of high-pressure gases
superoxide dismutase Free radical paraquat methyl viologen Escherichia coli
2009/7/14
This study was designed to test whether free radicals are involved in the deleterious effects of compressed gases on cells. The actions of xenon, nitrous oxide, argon, nitrogen, helium, and oxygen and...
The effect of high pressure on the kinetics of monoamine transmitters in the rat brain
drug hyperbaric serotonin noradrenaline dopamine animal rat monoamine transmitter
2009/7/14
The effects of 71 ATA pressure on the turnover of serotonin (5-HT), noradrenaline (NA), and dopamine (DA) were studied. High pressure increased the concentration of the 5-HT metabolite 5-hydroxyindole...
High hydrostatic pressure and chromate-induced effects on cell cycle kinetics
cell cycle kinetic chromate Glioma animal
2009/7/14
Cell cycle kinetics was studied using the quenching of 33258 Hoechst fluorescence by bromodeoxyuridine incorporation to investigate effects of high pressure on the toxicity of a welding fume component...
Effect of hydrostatic pressure on plasma concentrations of norepinephrine during cold water immersion
human plasma norepinephrine thermal immersion
2009/7/14
Head-out immersion of humans in cold water concurrently stimulates low-pressure receptors and cutaneous cold receptors. In theory, the low-pressure receptors inhibit sympathetic nerve activity to the ...
Intraosseous pressure changes during simulated dives: fact or transducer artifact?
Intraosseous pressure bone animal rabbit
2009/7/14
Anesthetized rabbits were placed in a compression chamber and the intraosseous pressure (IOP) in one femur was recorded during simulated dives to a depth of 20 m. No change in IOP was observed during ...
High hydrostatic pressure potentiation of the toxic effects of chromate in cell culture
human chromate cell culture commercial welding
2009/7/14
Development of hyperbaric welding has created the need for new occupational health standards. We have used cell cultures to investigate effects of high pressure chromate on the toxicity of the welding...
Components of the pressure required to breathe dense gases
human Respiration dense gas lung work of breathing
2009/7/14
To elucidate the impact of high gas density on airway flow (during inspiration and expiration) and on gas acceleration (at end-inspiration and end-expiration), I simulated pressures for breathing in m...
A versatile chamber for microphysiologic studies with gas mixtures under high pressure
chamber microphysiologic high pressure chamber micromanipulator
2009/7/14
A pressure chamber, designed for microelectrode recordings in isolated tissues or organs an capable of withstanding pressures up to 200 bar, is described. The versatility of the vessel allows a wide v...
Ventilatory failure in cats during prolonged exposure to very high pressure
helium heliox muscle fatigue respiratory Ventilatory failure animal cat high density gas
2009/7/14
Ten adult, awake cats were exposed to high pressure (7.5, 9, or 10 MPa) of a heliox (He-O2) or trimix (He-N2-O2) gas mixture. Total duration of the experiment, i.e., duration of compression plus sojou...
High ambient pressure of 41 bar increases the cerebral toxicity of penicillins
animal rat drug
2009/7/10
Sodium benzylpenicillin, cloxacillin, and azlocillin were infused intravenously in awake rats at 1 and 41 bar until they convulsed. The doses necessary to elicit convulsions were significantly lower a...
Transcutaneous measurement of PCO2 at high ambient pressure (41 bar)
transcutaneous oxygen CO2 carbon dioxide animal rat hyperbaric
2009/7/10
The accuracy of transcutaneous CO2 monitoring with the Kontron CO2 sensor was studied during compression to 41 bar and subsequent decompression. The PCO2 was stable and accurate during the test of the...
Pressure suppresses serotonin release by guinea pig striatal synaptosomes
animal guinea pig serotonin striatal synaptosomes high pressure nervous syndrome
2009/7/10
Exposure to high pressure produces neurologic changes in humans which manifest as tremor, EEG changes, and convulsions. Since previous studies have implicated the involvement of the serotoninergic sys...