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IN VITRO SEMI-QUANTITATIVE DETERMINATAION OF HUMAN GAMMA-INTERFERON EXPRESSION BY RT-PCR
semi-quantitative IFN-γ PHA
2010/4/12
Secreted cytokines of Th1 (T-helper)/Th2 cells play an important role in the pathogenesis of many diseases. Th1 cells secrete predominantly IFN-γ and IL-2 which regulate cell-mediated immunity against...
Adrenomedullin stimulates cyclic AMP production in the airway epithelial cells of guinea-pigs and in the human epithelial cell line
adrenomedullin airway cAMP epithelial cell guinea-pig human
2010/11/26
This study was designed to examine the effects of adrenomedullin (AM) on airway epithelial cells. Primary cultures of guinea-pig tracheal epithelial cells and the human bronchiolar epithelial cell lin...
Differentiation of naive human CD4+ T cells into Th2 cells: The role of prostaglandin E2
interleukin naive CD4+ T cells prostaglandin E2 T-helper 2 cells
2010/11/26
T-helper (Th) 2 cells, which produce interleukin (IL)-4, IL-5, IL-10 and IL-13 upon stimulation of their T cell receptors, play an important role in the development of human allergic diseases. However...
A novel venom protein of the Asian bee (Apis cerana indica) with an affinity to human α1-microglobulin
α1-microglobulin Asian bee bee venom inflammatory reaction
2010/11/29
Bee stings are a common health problem throughout the world and can sometimes result in fatal anaphylactic reactions. We have studied Asian bee (Apis cerana indica, Apis cerana nigrocincta and Apis do...
Molecular regulation of human IgE synthesis
atopy CD40 ligand IgE interleukin-4 switch recombination
2010/11/29
Human IgE synthesis is largely dependent on the production of interleukin (IL)-4 or IL-13 and the expression of CD40 ligand. Such B cell help is not only provided by CD4+ T cells, but also by CD8+ T c...
Production of Matrix Metalloproteinases in Human Cultured Mast Cells: Involvement of Protein Kinase C—Mitogen Activated Protein Kinase Kinase—Extracellular Signal-regulated Kinase Pathway
human cultured mast cells matrix metalloproteinase-9 membrane type matrix metalloproteinase tissue inhibitor of metalloproteinase-1 tissue inhibitor of metalloproteinase-2
2010/11/18
We detected the de novo synthesis of MMP-9 in HCMC after stimulation with PMA and found that the synthesis was mediated through protein kinase C—mitogen activated protein kinase kinase (MEK)—ERK pathw...
Eotaxin-induced expression of membrane type 1 matrix metalloproteinase mRNA in human eosinophils
basement membrane degradation eosinophil eotaxin matrix metalloproteinase-2 matrix metalloproteinase-9 membrane-type matrix metalloproteinase
2010/11/25
Eosinophil penetration across the basement membrane (BM) is thought to be dependent on the degradation of membrane components. In this process, matrix metalloproteinases (MMP) appear to be primarily r...
Non-specific activation of human eosinophil functional responses by vasoactive intestinal peptide
allergic inflammation eosinophil functional response signal transduction vasoactive intestinal peptide
2010/11/25
Eosinophils and neuropeptides are thought to play effector roles in allergic diseases, such as rhinitis; however, little is known about the biological effects of neuromediators, especially vasoactive ...
Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts
fibronectin human lung fibroblast interleukin-4 interleukin-13 remodeling
2010/11/25
The results showed that IL-4 and IL-13 induced fibronectin production in a time- and a concentration-dependent manner. Anti-transforming growth factor (TGF)-β1 antibody (ab) inhibited TGF-β1-induced f...
Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils
antiallergic drug human eosinophils leukotriene olopatadine
2010/11/25
Olopatadine hydrochloride (olopatadine; KW-4679), (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride, is an antiallergic drug with selective and potent...
Effect of macrolides on the expression of human leukocyte antigen-DR and costimulatory molecules on cultured human mononuclear cells
CD54 CD80 CD86 costimulatory molecules human leukocyte antigen-DR macrolides monocytes
2010/11/25
Although the clinical effectiveness of long-term low-dose administration of macrolides for diffuse pan- bronchiolitis, sinobronchial syndrome, chronic sinusitis and otitis media with effusion has been...
Mechanical strain-induced DNA synthesis and cell proliferation in human airway smooth muscle cells through extracellular signal-regulated kinase
airway smooth muscle cell extracellular signal-regulated kinase mechanical strain
2010/11/25
An increased airway muscle content is one of the characteristic features of airway remodeling. Proinflammatory substances, growth factors and mechanical strain promote airway muscle cell proliferation...
Inhalant corticosteroids inhibit mechanical strain-induced RANTES and eotaxin production by human airway smooth muscle cells
airway smooth muscle cells eotaxin inhaled corticosteroids mechanical strain RANTES
2010/11/24
The results showed that: (i) mechanical strain, including stretch and compression, stimulated ASM cells to produce RANTES and eotaxin; and (ii) FP and BUD inhibited mechanical strain-induced and TNF-α...
Association of IgG Fc receptor II with tyrosine kinases in the human basophilic leukemia cell line KU812F
basophilic leukemia cell line IgG Fc receptor II intracellular calcium mobilization signal transduction tyrosine kinase
2010/11/24
The tyrosine kinase inhibitor genistein inhibited intracellular calcium mobilization caused by cross-linking of FcγRII in a dose-dependent manner. Rapid tyrosine phosphorylation after FcγRII cross-lin...
A rapid and sensitive HPLC method for the analysis of metronidazole in human plasma: application to single dose pharmacokinetic and bioequivalence studies
Metronidazole HPLC Pharmacokinetics Bioavailability
2010/2/4
A sensitive, accurate and rapid reverse phase HPLC method was developed to quantitate plasma levels of metronidazole in order to conduct a comparative bioavailability studies. The drug and internal st...