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Measuring Electrostatic Fields in Both Hydrogen Bonding and non-Hydrogen Bonding Environments using Carbonyl Vibrational Probes
Ribonucleases Molecular Probes Protein Conformation Vibration Acetophenones Molecular Dynamics Simulation Static Electricity Hydrogen Bonding Solvents
2016/5/25
Vibrational probes can provide a direct readout of the local electrostatic field in complex molecular environments, such as protein binding sites and enzyme active sites. This information provides an ...
Electrostatic Fields Near the Active Site of Human Aldose Reductase:1.New Inhibitors and Vibrational Stark Effect Measurements
apoptosis ATM cisplatin IKK p73 ubiquitination
2016/5/25
Vibrational Stark effect spectroscopy was used to measure electrostatic fields in the hydrophobic region of the active site of human aldose reductase (hALR2). A new hALR2 inhibitor was designed and sy...
Site-Specific Conversion of Cysteine Thiols into Thiocyanate Creates an IR Probe for Electric Fields in Proteins
food packaging perfluorinated dietary intake human exposure
2016/5/24
The nitrile stretching mode of the thiocyanate moiety is a nearly ideal probe for measuring the local electric field arising from the organized environment of the interior of a protein. Nitriles were ...
Vibrational Stark Effects Calibrate the Sensitivity of Vibrational Probes for Electric Fields in Proteins
transitional cell carcinoma cDNA microarray molecular markers expression profiling tumor classification
2016/5/24
Infrared spectroscopy is widely used to probe local environments and dynamics in proteins. The introduction of a unique vibration at a specific site of a protein or more complex assembly offers many a...
Energetics of Primary Charge Separation in Bacterial Photosynthetic Reaction Center Mutants:Triplet Decay in Large Magnetic Fields
horseradish peroxidase lignin peroxidase enzymatic oxidations N-demethylation methylene blue azure B azure C
2016/5/24
The triplet state of aromatic molecules forms and decays by intersystem crossing, as originally demonstrated by Kasha and Lewis. By contrast, the triplet state of the primary electron donor, 3 P, in p...
Vibrational Stark Spectroscopy in Proteins:A Probe and Calibration for Electrostatic Fields
affinity partition plasma membrane IGF-I receptor C6 glioma wheat germ agglutinin two-phase partitioning
2016/5/23
We report the first measurement of the vibrational Stark effect in a protein, providing quantitative information on the sensitivity of a vibrational transition to an applied electric field. This can b...
Effects of Applied Electric Fields on the Quantum Yields of the Initial Electron-Transfer Steps in Bacterial Photosynthesis.1.Quantum Yield Failure
Applied Electric Fields Quantum Yields Initial Electron-Transfer Steps Bacterial Photosynthesis.1.Quantum
2016/5/23
The effect of an applied electric field has been measured for the quantum yield of formation of the P[sup +]H[sup [minus]], P[sup +]Q[sub A][sup [minus]], and [sup 3]P states of nonoriented Rb. sphaer...
The Effect of Very High Magnetic Fields on the Reaction Dynamics in Bacterial Reaction Centers:Implications for the Reaction Mechanism
Reactioncenter Photosynthesis Bacterialphotosynthesis Delayedfluorescence Magnetic fieldeffect (Rb. sphaeroides)
2016/5/23
Magnetic field effects have proven to be a powerful tool for elucidating the mechanism of the initial charge separation and recombination steps in bacterial photosynthesis. Since the first data were o...
The Effect of Very High Magnetic Fields on the Delayed Fluorescence from Photosynthetic Reaction Centers
Reactioncenter Photosynthesis Bacterialphotosynthesis Delayedfluorescence Magneticfieldeffect (Rb. sphaeroides)
2016/5/23
Delayed fluorescence is observed from quinone-depleted Rhodobacter sphaeroides reaction centers due to re-formation of the excited state of the special pair electron donor from the initially formed ra...
Energetics of Initial Charge Separation in Bacterial Photosynthesis:The Triplet Decay Rate in Very High Magnetic Fields
Photosynthesis Electron transfer Reaction center Magnetic field effect primary electron acceptor primary electron donor quinone
2016/5/20
The triplet state of the primary electron donor is formed in bacterial reaction centers when electron transfer to the quinone is blocked. The relative quantum yield of formation and the rate of decay ...
A variety of animals are able to sense and react to electric fields, and living human cells will move along an electric field, for example in wound healing. Now a team lead by Min Zhao at the UC Davis...
Hippocampal Episode Fields Develop With Learning
hippocampus delay context place cell episode field
2015/8/7
Several recent studies have shown that hippocampal neurons fire during the delay period in between trials and that these firing patterns differ when different behaviors are required, suggesting that t...
Many living things can respond to electric fields, either moving or using them to detect prey or enemies. Weak electric fields may be important growth and development, and in wound healing: it’s known...
Stochastic quantization of fields inspired by biological evolution
Stochastic quantization biological evolution
2011/1/6
The quasi-species equation describes the evolution of the probability that a random individual in a population carries a given genome. Here we map the quasi-species equation for individuals of a self-...
Profile conditional random fields for modeling protein families with structural information
sequence analysis structure prediction fold recognition dynamic programming mean field approximation
2010/12/2
A statistical model of protein families, called profile conditional random fields (CRFs), is proposed. This model may be regarded as an integration of the profile hidden Markov model (HMM) and the Fin...