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Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies
cobalamin c.776G>C genetic association studies
2018/11/20
Background: Vitamin B-12 (cobalamin) deficiency may produce severe neurologic and hematologic manifestations. Approximately 20–25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is r...
Population Structure and Cryptic Relatedness in Genetic Association Studies
Population Structure Cryptic Relatedness Genetic Association Studies
2010/11/16
We review the problem of confounding in genetic association studies, which arises principally because of population structure and cryptic relatedness. Many treatments of the problem consider only a si...