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吉林大学动物科学学院李占军教授团队在Science Advances发表研究成果：利用dCas9协助CRISPR Type I-E实现大片段基因组精确敲除（图）
李占军 Science Advances dCas9 CRISPR Type I-E 基因组
2024/5/9
2024年3月15日，动物科学学院李占军教授团队在Science子刊《Science Advances》期刊发表了题为“Precise large-fragment deletions in mammalian cells and mice generated by dCas9-controlled CRISPR/Cas3”的研究成果。该研究证明了dCas9可用于精确调控Type I-E介导的DN...
2023年8月29日，中国农业大学国家玉米改良中心、玉米生物育种全国重点实验室赖锦盛教授团队在Plant Biotechnology Journal 上在线发表了题为“Targeted large fragment deletion in plants using paired crRNAs with type I CRISPR system”的研究论文。该研究利用Type I CRISPR系统，...
近日，安徽农业大学农学院魏鹏程课题组和河南大学作物逆境生物学国家重点实验室陆平利课题组合作在Plant Biotechnology Journal上发表了题为“Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice”的研究论文。该研究基于两个NmCas9蛋白，Nm1Cas9和NmCa...
对病原DNA的免疫识别，是宿主细胞感知病原感染的重要手段，这种免疫响应广泛存在于从低等原核生物到高等哺乳动物当中（图1）。哺乳动物细胞利用多条天然免疫通路识别病原DNA并介导免疫应答；细菌则主要依赖"R-M系统"及"CRISPR-Cas系统"来去除入侵的噬菌体DNA。限制修饰（Restriction-Modification；R-M）系统被称为细菌的天然免疫系统，可对宿主自身DNA进行甲基化修饰，...
A type of virus that dominates water samples taken from the world’s oceans has long escaped analysis because it has characteristics that standard tests can’t detect. However, researchers at MIT and th...
Genetic relationship between type traits, number of lactations initiated, and lifetime milk performance in Czech Fleckvieh cattle
dairy cows longevity lifetime performance conformation traits
2017/12/25
Genetic relationship was analyzed between type traits and longevity measures in dual-purpose cattle. Data from 91 486 Czech Fleckvieh cows first calved between 2003 and 2009 were used. Longevity was d...
A systematic review and meta-analysis of nutrition therapy compared with dietary advice in patients with type 2 diabetes
dietary advice individualized nutrition therapy meta-analysis review type 2 diabetes
2018/11/21
Background: Despite recommendations, many patients with type 2 diabetes receive dietary advice from nurses or doctors instead of individualized nutrition therapy (INT) that is provided by a dietitian.
Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes
trimethylamine-N-oxide type 2 diabetes flavin monooxygenase 3 polymorphisms nutrition metabolite
2018/11/19
Background: The association of trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent.
Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes
trimethylamine-N-oxide type 2 diabetes flavin monooxygenase 3 polymorphisms, nutrition metabolite
2018/11/16
Background: The association of trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite from dietary choline and carnitine, with type 2 diabetes was inconsistent.
Genetic relationship between type traits, number of lactations initiated, and lifetime milk performance in Czech Fleckvieh cattle
dairy cows longevity lifetime performance conformation traits genetic correlation
2018/3/5
Genetic relationship was analyzed between type traits and longevity measures in dual-purpose cattle. Data from 91 486 Czech Fleckvieh cows first calved between 2003 and 2009 were used. Longevity was d...
Effect of carbohydrate restriction in the first meal after an overnight fast on glycemic control in people with type 2 diabetes: a randomized trial
carbohydrate continuous glucose monitoring glucose postprandial type 2 diabetes
2018/12/18
Background: People with type 2 diabetes are advised to consume an even meal distribution of carbohydrate. Whether this distribution is optimal is unknown.
Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies
animal protein dietary protein meta-analysis plant protein prospective study type 2 diabetes
2018/12/18
Background: Reported associations between protein intake from different sources and type 2 diabetes (T2D) have been inconsistent.
Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study
calcium-sensing receptor polymorphism cohort study diabetes mellitus race serum calcium
2018/12/14
Background: Elevated serum calcium has been associated with a variety of metabolic abnormalities and may be associated with a greater risk of diabetes.
Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and risk of type 2 diabetes in Scandinavian men and women
type 2 diabetes whole grains biomarker alkylresorcinols nested case-control studies
2018/12/3
Background: Studies that use dietary biomarkers to investigate the association between whole-grain intake and the risk of developing type 2 diabetes (T2D) are lacking.
Electrostatic Interactions in Wild Type and Mutant Recombinant Human Myoglobins
SUBSTANCE-P GABA PROLACTIN ANTERIOR PITUITARY HYPOTHALAMIC FRAGMENTS ANTI-SUBSTANCE-P SERUM
2016/5/20
Residue Val68 in human myoglobin has been replaced by Asn, Asp, and Glu with site-directed mutagenesis. Purified proteins were characterized by isoelectric focusing and by absorption, CD, and NMR spec...