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Role of Voltage-Dependent K+ and Ca2+ Channels in Coronary Electromechanical Coupling: Effects of Metabolic Syndrome
blood flow obesity metabolic syndrome
2015/5/22
Regulation of coronary blood flow is a highly dynamic process that maintains the delicate balance between oxygen delivery and metabolism in order to preserve cardiac function. Evidence to date support...
T he relative order of mK channels, free radicals and p38 MAPK in ATP preconditioning’s protective pathway in rat heart
Free radicals Infarction Ischemia Mitochondria Preconditioning Signal transduction
2014/3/31
Ischemic preconditioning (PC) reduces myocardial infarction by a mechanism that involves opening of mitochondrial
ATP-dependent potassium channels (mK ), reactive oxygen species (ROS), and possibly a...
Activation of Mitochondrial ATP-Dependent Potassium Channels by Nitric Oxide
ischemic preconditioning nitric oxide myocytes mitochondria
2014/3/31
We measured mitochondrial redox potential as an index of mitoKATP
channel opening in rabbit
ventricular myocytes. The NO donor S-nitroso-N-acetyl- DL-penicillamine (SNAP, 0.1 to 1 mmol/L) oxidized t...
Ion Channels and Their Functional Role in Vascular Endothelium
Ion Channels Their Functional Role Vascular Endothelium
2014/3/31
Endothelial cells (EC) form a multifunctional signaltransducing surface that performs different tasks dependent on its localization in the vessel tree. Arterial EC provide a pathway for delivery of ox...
The Voltage Sensor in Voltage-Dependent Ion Channels
Voltage Sensor Voltage-Dependent Ion Channels
2014/3/31
The remarkable work of Hodgkin and Huxley (39) set the physical basis of the nerve impulse generation and propagation using the giant axon of the squid as a model.In their description, the initiation ...