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目的: 探讨将人双突变的二氢叶酸还原酶基因(DHFR)和胞苷脱氨基酶基因(CD)同时导入小鼠骨髓细胞中，观察小鼠对大剂量氨甲喋呤(MTX)和阿糖胞苷(Ara-C)的耐受性，研究骨髓耐受联合化疗的可行性. 方法: 以反转录病毒为载体，将人双突变的二氢叶酸还原酶基因(DHFR)和胞苷脱氨基酶基因(CD)通过共培养转染入小鼠骨髓干细胞，观察共培养后的骨髓细胞及受体小鼠骨髓移植后经药物处理后的骨髓细胞耐M...
A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users
Folate dihydrofolate reductase DHFR one-carbon metabolism breast cancer multivitamins prospective study
2008/12/12
Background:Dihydrofolate reductase (DHFR) converts dihydrofolate (DHF) into tetrahydrofolate (THF) and plays an essential role in cell metabolism and cellular growth. Folic acid from multivitamins nee...