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Effect of anandamide in improving of the non-adrenergic non-cholinergic relaxation of the corpus cavernosum from diabetic rats
Diabetes mellitus erectile dysfunction anandamide cannabinoid system nitric oxide corpus cavernosum
2009/12/16
Background: It is well known that erectile dysfunction is most commonly associated with diabetes, affecting 35% to 75% of men with diabetes mellitus. Several studies have been carried out to find appr...
CONTROL OF ENVIRONMENTAL HEALTH AND REMOVAL OF RATS BY 2-ADRENERGIC ANTAGONIST AND POTASSIUM CHANNEL BLOCKER
KATP channel POTASSIUM CHANNEL BLOCKER
2010/4/6
In the present study, it is shown that in vivo oral administration of glibenclamide (1-10 mg/kg/day), an adenosine triphosphate -sensitive potassium channel blocker, and yohimbine (1-5 mg/kg/day), an ...
β2-Adrenergic receptors: Structure, regulation and signaling by partial and full agonists
β2-adrenergic receptor selective agonist agonist-specific conformation constitutively active receptor
2010/11/22
It is believed that G-protein-coupled receptors are the most promising target proteins for drug research. The β2-adrenergic receptor has been analyzed extensively in terms of its structure, regulation...
Determination of the Intrinsic Efficacies of β2 -adrenergic Agonists
efficacy epinephrine fenoterol procaterol β2-adrenergic agonist
2010/11/19
β-adrenergic agonists have been traditionally classified as strong or weak. Attempts to express their effectiveness in quantitative terms has led to the concepts of potency, which designates the conce...